标题：急性髓系白血病合并毛霉菌病和多重耐药菌混合感染一例

      作者：谢娇娇，何燕芳，马燕花，郭才，郑兰兰    谢娇娇，何燕芳，马燕花，郭才，郑兰兰甘肃中医药大学第一临床医学院，甘肃 兰州 730000

      卷次： 2024年35卷3期

      【摘要】 白血病继发毛霉菌和多重耐药菌(MDRO)混合感染少见报道，该病进展快、诊断困难，严重时可危及生命。本文描述了1例合并毛霉菌病和多重耐药菌混合感染的急性髓系白血病(AML)老年患者，前期联合多种抗菌药物抗感染后病情未见好转，后期采用宏基因组二代测序(mNGS)及时明确病原菌后给予患者两性霉素B脂质体(LFAB)联合泊沙康唑(Pcz)及其他抗菌药物治疗，感染最终得以有效控制。
      【关键词】 毛霉菌病；多重耐药菌；急性髓系白血病；宏基因组二代测序；感染
      【中图分类号】 R733.71 【文献标识码】 D 【文章编号】 1003—6350（2024）03—0407—05

Acute myeloid leukemia complicated with mucormycosis and multi-drug resistant bacteria infection: a casereport.
XIE Jiao-jiao, HE Yan-fang, MA Yan-hua, GUO Cai, ZHENG Lan-lan. The First Clinical Medical College ofGansu University of Chinese Medicine, Lanzhou 730000, Gansu, CHINA【Abstract】 Mixed infection of mucormycosis and multi-drug resistant bacteria (MDRO) in leukemia is rarely re-ported. The disease progresses rapidly, is difficult to diagnose, and can be life-threatening in severe cases. This paper de-scribes an elderly patient with acute myeloid leukemia (AML) who was infected with mucormycosis and multi-drug re-sistant bacteria. The condition of AML did not improve after anti-infection with multiple antibiotics in the early stage. Inthe later stage, metagenomic next generation sequencing (mNGS) was used to identify the pathogenic bacteria in time,and the patients were given lipid formulation of amphotericin B (LFAB) combined with posaconazole (Pcz) and other an-tibacterial drugs, which effectively controlled the infection and gradually improved the symptoms of the patients.
      【Key words】 Mucormycosis; Multi-drug resistant bacteria; Acute myeloid leukemia; Metagenomic next genera-tion sequencing; Infection