标题：注射用丹参多酚酸对脑梗死患者神经功能及炎症指标的影响

      作者：孟欣，陈燕，夏玲玲，韩韦姣，常红娟    孟欣，陈燕，夏玲玲，韩韦姣，常红娟新乡市第二人民医院神经内科，河南 新乡 453002

      卷次： 2024年35卷3期

      【摘要】 目的 观察注射用丹参多酚酸用于改善脑梗死患者神经功能及炎症指标的效果。方法 选取2020年10月至2022年9月新乡市第二人民医院神经内科收治的100例脑梗死患者(发病在6~72 h内)作为研究对象，通过简单随机法将患者分为观察组和对照组，每组50例。所有患者入院后均常规给予抗血小板、抗动脉硬化以及抗神经损伤治疗，观察组患者在常规治疗基础上静脉滴注丹参多酚酸注射液0.13 g，1次/d，连用两周。比较两组患者治疗前后的神经损伤程度[采用美国国立卫生研究院卒中量表(NIHSS)评估]和外周静脉血中C反应蛋白(CRP)和白细胞介素(IL-6、IL-8)水平。结果 治疗前，两组患者的NIHSS评分比较差异无统计学意义(P>0.05)；治疗两周后，两组患者的NIHSS评分较治疗前均降低，且观察组的NIHSS评分为(5.14±1.69)分，明显低于对照组的(7.46±2.25)分，差异均有统计学意义(P<0.05)。治疗前，两组患者的血清CRP、IL-6、IL-8水平比较差异均无统计学意义(P>0.05)；治疗两周后，两组患者的血清CRP、IL-6、IL-8水平较治疗前降低，且观察组的上述各项指标分别为(5.33±2.14) mg/L、(7.47±2.22) ng/L、(16.51±5.71) μg/L，明显低于对照组的(8.85±9.03) mg/L、(10.836 0±4.34) ng/L、(25.562±6.57) μg/L，差异均有统计学意义(P<0.001)。结论 脑梗死患者在常规治疗的基础下采用注射用丹参多酚酸治疗可进一步减轻神经损伤程度和炎症反应，从而提升疗效。
      【关键词】 脑梗死；注射用丹参多酚酸；神经功能；炎症反应
      【中图分类号】 R743.33 【文献标识码】 A 【文章编号】 1003—6350（2024）03—0400—04

Effects of salvianolic acid for injection on neurological function and inflammatory markers in patients withcerebral infarction.
MENG Xin, CHEN Yan, XIA Ling-ling, HAN Wei-jiao, CHANG Hong-juan. Department ofNeurology, the Second People's Hospital of Xinxiang, Xinxiang 453002, Henan, CHINA
【Abstract】 Objective To observe the effect of salvianolic acid for injection on improving neurological func-tion and inflammatory indicators in patients with cerebral infarction. Methods From October 2020 to September 2022,100 patients with acute cerebral infarction (onset within 6-72 hours) admitted to Department of Neurology, the Second Peo-ple's Hospital of Xinxiang were selected and randomly divided into an observation (50 cases) and a control group (50 cas-es). After admission, all patients were routinely given anti-platelet and anti-arteriosclerosis medication, and treatmentagainst nerve damage, and patients in the observation group was also administered salvianolic acid injection 0.13 g intra-venously once a day for two weeks based on routine treatment. National Institutes of Health Stroke Scale (NIHSS) wasused to evaluate and compare the degree of nerve damage between two groups of patients. C-reactive protein (CRP) andinterleukin-6 (IL-6, IL-8) in peripheral venous blood were measured and compared between the two groups of patients.Results Before treatment, there was no statistically significant difference in NIHSS scores between the two groups ofpatients (P>0.05); after two weeks of treatment, the NIHSS scores of both groups of patients decreased compared tothose before treatment, and the NIHSS score of the observation group was (5.14±1.69) points, significantly lower thanthe control group's (7.46±2.25) points, with statistically significant differences (P<0.05). Before treatment, there was nostatistically significant difference in serum CRP, IL-6, and IL-8 levels between the two groups of patients (P>0.05); af-ter two weeks of treatment, the serum levels of CRP, IL-6, and IL-8 in both groups of patients decreased compared tothose before treatment, and the above indicators in the observation group were (5.33±2.14) mg/L, (7.47±2.22) ng/L, and(16.51±5.71) μg/L, respectively, significantly lower than the control group's (8.85±9.03) mg/L, (10.836 0±4.34) ng/L,and (25.562±6.57) μg/L; the differences were statistically significant (P<0.001). Conclusion Salvianolic acid for injec-tion based on routine treatment can improve the therapeutic efficacy and further reduce the degree of nerve injury and in-flammation in patients with cerebral infarction.
      【Key words】 Cerebral infarction; Salvianolic acid for injection; Neural function; Inflammatory response