标题：我院2019—2022年体检者与门诊患者HPV感染情况分析

      作者：王文惠，张怡，陆心怡，杨卫华    上海宝山中西医结合医院检验科，上海 201999

      卷次： 2023年34卷24期

      【摘要】 目的 调查我院近4年的体检者与门诊患者人乳头瘤病毒(HPV)的感染情况。方法 选取2019年1月至2022年12月上海宝山中西医结合医院的1 885名体检者和15 569例门诊患者为研究对象。采集所有受检者阴道或尿道分泌物样本，采用聚合酶链反应(PCR)-反向斑点杂交法进行HPV感染检测。记录所有体检者与门诊患者HPV感染和感染类型情况，以及不同性别、年龄受检者的感染情况。结果 2019年、2020年、2021年、2022年HPV感染率分别为 18.98% (97/511)、39.53% (17/43)、17.16% (1 607/9 365)、15.05% (1 134/7 535)；体检者、门诊患者HPV感染率均呈先升高后降低的趋势，其中以 2020年[21.43% (3/14)，48.28% (14/29)]最高，2022年[15.05%(1 134/7 535)，15.88% (1 066/6 712)]最低。HPV单一感染率呈先升高后降低再升高的趋势，其中以2020年[82.35%(14/17)]最高，2021年[61.54% (989/1607)]最低；HPV多重感染率呈先降低后升高再降低的趋势，其中以 2021年[38.46% (618/1 607)]最高，2020年[17.65% (3/17)]最低。体检者、门诊患者HPV单一感染率在2019—2021年呈先升高后降低的趋势，2022年又有所升高，而多重感染率变化趋势则与之相反。女性 2020年的HPV感染率为36.84%(7/19)，明显高于 2019年的 15.33% (69/450)，在 2021—2022年呈逐渐降低的趋势；男性HPV感染率在 2019—2021年呈逐渐降低的趋势，2022年又有所升高；随着年龄的增长，女性、男性HPV感染率均呈先升高后降低的趋势，且在21~40岁、41~60岁阶段的感染率较高。结论 我院 2019—2022年体检者与门诊患者感染均以单一感染为主。HPV感染可能多发于男性，且男性、女性HPV感染均多发于21~40岁、41~60岁阶段。
      【关键词】 上海；体检；门诊；人乳头瘤病毒；感染；调查
      【中图分类号】 R194.3 【文献标识码】 A 【文章编号】 1003—6350（2023）24—3604—05

HPV infection among subjects undergoing physical examination and outpatients in our hospital from 2019 to2022.
WANG Wen-hui, ZHANG Yi, LU Xin-yi, YANG Wei-hua. Department of Laboratory, Shanghai Baoshan TraditionalChinese and Western Medicine Hospital, Shanghai 201999, CHINA
【Abstract】 Objective To investigate the human papilloma virus (HPV) infection among subjects undergoingphysical examination and outpatients in our hospital in recent 4 years. Methods A total of 1 885 subjects undergoingphysical examination and 15 569 outpatients in Shanghai Baoshan Traditional Chinese and Western Medicine Hospitalfrom January 2019 to December 2022 were selected. Samples of vaginal or urethral secretion were collected from all sub-jects, and HPV infection was detected by polymerase chain reaction (PCR)-reverse dot blot. HPV infection and infectiontypes of subjects undergoing physical examination and outpatients and the infection in subjects of different genders andages were recorded from 2019 to 2022. Results In 2019, 2020, 2021, 2022, HPV infection rates were 18.98% (97/511),39.53% (17/43), 17.16% (1 607/9 365), 15.05% (1 134/7 535), respectively. The HPV infection rate of subjects undergo-ing physical examination and outpatients were increased first and then decreased, with the highest rate in 2020 [21.43%(3/14), 48.28% (14/29)] and the lowest rate in 2022 [15.05% (1 134/7 535), 15.88% (1 066/6 712)]. The single infectionrate of HPV increased first, then decreased, and then increased, with the highest rate in 2020 [82.35% (14/17)] and thelowest rate in 2021 [61.54% (989/1 607)]. The multiple infection rate of HPV decreased first, then increased, and then de-creased, with the highest rate in 2021 [38.46% (618/1 607)] and the lowest rate in 2020 [17.65% (3/17)]. The single in-fection rate of HPV of subjects undergoing physical examination and outpatients showed a trend of first increase andthen decrease from 2019 to 2021, and increased again in 2022, while the trend of multiple infection was opposite. TheHPV infection rate of females in 2020 was 36.84% (7/19), which was higher than 15.33% (69/450) in 2019, which showeda gradually decreasing trend in 2021-2022. HPV infection rate of males were gradually decreased from 2019 to 2021, andincreased again in 2022. With the increase of age, the infection rate of HPV in females and males showed a trend of in-creasing first and then decreasing, and the infection rate was higher in 21-40 and 41-60 years old. Conclusion HPV in-fection among subjects undergoing physical examination and outpatients in our hospital from 2019 to 2022 were mainlysingle infections. HPV infection may be more common in males, and HPV infection in both males and females was morecommon in 21-40 and 41-60 years old.
      【Key words】 Shanghai; Physical examination; Outpatient; Human papilloma virus; Infection; Investigation