标题：乙型肝炎病毒核心抗体定量检测研究进展

      作者：陈翔宇 1，2 综述 张海峰 1，3审校    陈翔宇 1，2 综述 张海峰 1，3审校1.南通大学附属医院感染科，江苏 南通 226001；2.南通大学医学院，江苏 南通 226001；3.新疆克孜勒苏柯尔克孜自治州人民医院感染科，新疆 阿图什 845350

      卷次： 2023年34卷23期

      【摘要】 近年来多项研究发现乙型肝炎病毒核心抗体检测与抗病毒药物治疗应答、区分慢乙肝不同自然史时期、免疫抑制治疗后乙型肝炎病毒(HBV)再激活等相关，有望成为启动抗病毒治疗、预测疗效、判断预后的重要参考指标，具有巨大临床应用潜力。本文就乙型肝炎病毒核心抗体(抗HBc)检测的最新研究进展和临床意义进行综述，为早日实现对慢性HBV感染者的精准化、个体化治疗提供帮助。
      【关键词】 乙型肝炎病毒核心抗体；慢性HBV感染自然史；疗效预测；隐匿性乙型肝炎病毒感染；HBV再激活
      【中图分类号】 R512.6+2 【文献标识码】 A 【文章编号】 1003—6350（2023）23—3492—05

Clinical research advances in quantitative detection of core antibody of hepatitis B virus.
CHEN Xiang-yu 1,2,ZHANG Hai-feng 1,3. 1. Department of Infectious Diseases, Affiliated Hospital of Nantong University, Nantong 226001,Jiangsu, CHINA; 2. Medical College of Nantong University, Nantong 226001, Jiangsu, CHINA; 3. Department of InfectiousDiseases, Xinjiang Kyzylsu Kirgiz Autonomous Prefecture People's Hospital, Atush 845350, Xinjiang, CHINA【Abstract】 In recent years, many studies have found that the core antibody detection of hepatitis B virus is relat-ed to the response to antiviral drug treatment, the differentiation of different natural history periods of chronic hepatitisB, and Hepatitis B (HBV) reactivation after immunosuppressive treatment. It is expected to become an important refer-ence index for initiating antiviral therapy, predicting efficacy and judging prognosis, and has great clinical application po-tential. This paper summarizes the latest research progress and clinical significance of the detection of hepatitis B viruscore antibody (anti-HBc), so as to provide some help for the early realization of accurate and individualized treatment ofchronic HBV infected patients.
      【Key words】 Core antibodies of hepatitis B virus; Natural history of chronic HBV infection; Prediction of effica-cy; Occult hepatitis B virus infection; HBV reactivation