标题：皮炎消颗粒联合中药湿敷治疗颜面部过敏性皮炎疗效观察

      作者：郭慧敏 1，李燕妮 2，杜凡 3    1.延安市中医医院皮肤科，陕西 延安 716000；2.陕西省中医医院皮肤科，陕西 西安 710003；3.延安大学附属医院皮肤科，陕西 延安 716000

      卷次： 2023年34卷21期

      【摘要】 目的 观察皮炎消颗粒联合中药湿敷治疗颜面部过敏性皮炎的临床效果。方法 选取2020年6月至2022年6月在延安市中医医院皮肤科接受治疗的116例颜面部过敏性皮炎患者为研究对象，采取随机数表法分为对照组(采取中药湿敷治疗方式)和观察组(采取皮炎消颗粒联合中药湿敷治疗方式)各58例，于治疗1个月后比较两组患者的临床疗效，以及治疗前后的皮肤颜色指数、皮肤发热指数、皮肤瘙痒程度等积分和血清免疫球蛋白E(IgE)水平、嗜酸性粒细胞(EOS)数目变化；同时比较两组患者的不良反应发生情况。结果 观察组患者的治疗总有效率为74.14%，明显高于对照组的55.17%，差异有统计学意义(P<0.05)；观察组患者的皮肤颜色指数、发热指数及瘙痒程度积分分别为(0.69±0.12)分、(0.72±0.14)分及(0.83±0.23)分，明显低于对照组的(1.03±0.23)分、(1.21±0.32)分及(1.15±0.35)分，差异均有统计学意义(P<0.05)；观察组患者的血清总 IgE和 EOS分别为(109.07±16.45) IU/mL，(2.87±0.12)×109/mL，明显低于对照组的(116.23±16.43) IU/mL、(3.32±0.23)×109/mL，差异均具有统计学意义(P<0.05)；观察组患者治疗期间的不良反应总发生率为6.90%，略低于对照组的8.62%，但差异无统计学意义(P>0.05)。结论 皮炎消颗粒联合中药湿敷治疗颜面部过敏性皮炎不仅可缓解皮肤颜色发红、发热、瘙痒等症状，而且能改善患者的机体炎症水平，临床应用效果好且不良反应少。
      【关键词】 颜面部过敏性皮炎；皮炎消颗粒；中药湿敷；临床症状；免疫球蛋白E；血液嗜酸性粒细胞数
      【中图分类号】 R751.05 【文献标识码】 A 【文章编号】 1003—6350（2023）21—3114—05

Efficacy of Piyanxiao granule combined with traditional Chinese medicine wet compress in the treatment of facialallergic dermatitis.
GUO Hui-min 1, LI Yan-ni 2, DU Fan 3. 1.Department of Dermatology, Yan’an Hospital of TraditionalChinese Medicine, Yan'an 716000, Shaanxi, CHINA; 2.Department of Dermatology, Shaanxi Provincial Hospital of ChineseMedicine, Xi'an 710003, Shaanxi, CHINA; 3.Department of Dermatology, Yan'an University Affiliated Hospital, Yan'an716000, Shaanxi, CHINA
【Abstract】 Objective To observe the clinical effects of Piyanxiao granule combined with traditional Chinesemedicine wet compress in treating facial allergic dermatitis. Methods A total of 116 patients with facial allergic derma?titis who received treatment in Department of Dermatology, Yan’an Hospital of Traditional Chinese Medicine from June2020 to June 2022 were selected as the study objects. They were divided into a control group (traditional Chinese medi?cine wet compress) and an observation group (Piyanxiao granule combined with traditional Chinese medicine wet com?press) by the random number table method, with 58 patients in each group. The clinical efficacy after 1 month of treat?ment, the scores of skin color index, skin fever index, and skin itching degree, changes of serum immunoglobulin E(IgE) and eosinophil (EOS) count before and after treatment, and occurrence of adverse reactions were compared be?tween the two groups. Results The total effective rate of treatment in the observation group was 74.14%, which wassignificantly higher than 55.17% in the control group (P<0.05). The scores of skin color index, fever index, and itchingdegree in the observation group were (0.69±0.12) points, (0.72±0.14) points, and (0.83±0.23) points, which were signifi?cantly lower than (1.03±0.23) points, (1.21±0.32) points, and (1.15±0.35) points in the control group (P<0.05). The lev?els of serum total IgE and EOS count in the observation group were (109.07±16.45) IU/mL and (2.87±0.12)×109/mL,which were significantly lower than (116.23±16.43) IU/mL and (3.32±0.23)×109/mL in the control group (P<0.05). Thetotal incidence rate of adverse reactions during treatment in the observation group was 6.90%, which was slightly lowerthan 8.62% in the control group (P>0.05). Conclusion Piyanxiao granule combined with traditional Chinese medicine wetcompress in the treatment of facial allergic dermatitis can not only relieve the symptoms of skin redness, fever and itching, butalso improve the body’s inflammation level of patients, with good clinical application effect and few adverse reactions.
      【Key words】 Facial allergic dermatitis; Piyanxiao granule; Traditional Chinese medicine wet compress; Clinicalsymptoms; Immunoglobulin E; Blood eosinophil count