标题：溶血磷脂酸在眼部疾病作用中的研究进展

      作者：宋钊曦 综述 谭薇 审校    遵义医科大学第三附属医院眼科，贵州 遵义 563000

      卷次： 2023年34卷20期

      【摘要】 溶血磷脂酸(lysophosphatidic acid，LPA)是一种具有生物活性的天然甘油磷脂，它特异性地通过LPA受体与G蛋白耦连结合，通过多种途径参与细胞应激、信号传导、炎症反应、细胞保护等多种病理生理活动。LPA在眼部组织细胞中普遍存在并具有多种生理效应，如通过刺激角膜内皮细胞增殖促进角膜伤口愈合；诱导细胞外基质纤维化加重青光眼进展；通过晶状体上皮细胞增加游离钙浓度加重白内障的发展。此外，它在视网膜脱离和增殖性糖尿病视网膜病变的发生发展过程中也起着重要的作用。本文对LPA及其受体在眼部疾病作用中的研究进展给予综述。
      【关键词】 溶血磷脂酸；角膜愈合；白内障；青光眼；视网膜病变
      【中图分类号】 R771 【文献标识码】 A 【文章编号】 1003—6350（2023）20—3036—05

Research progress on the role of lysophosphatidic acid in ocular diseases.
SONG Zhao-xi, TAN Wei. Department ofOphthalmology, the Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHINA【Abstract】 Lysophosphatidic acid (LPA) is a natural glycerophosphatidic phospholipid with biological activity.LPA specifically binds to G protein through LPA receptor, and participates in a variety of pathophysiological activitiessuch as cell stress, signal transduction, inflammatory response, and cell protection through a variety of pathways. LPA isubiquitous in ocular tissues and cells and has a variety of physiological effects, such as promoting corneal wound healingby stimulating corneal endothelial cell proliferation. Extracellular matrix fibrosis is induced to aggravate the progressionof glaucoma. Increasing free calcium concentration by lens epithelial cells aggravates the development of cataract. In ad-dition, it also plays an important role in the occurrence and development of retinal detachment and proliferative diabeticretinopathy. This article reviews the research progress of LPA and its receptors in ocular diseases.
      【Key words】 Lysophosphatidic acid (LPA); Corneal wound healing; Glaucoma; Cataract; Retinopathy