标题：基底浆细胞增多预测溃疡性结肠炎复发风险的Meta分析

      作者：崔家玮 1，李秀娟 2，高鸿亮 1，张志强 1    崔家玮 1，李秀娟 2，高鸿亮 1，张志强 11.新疆医科大学第一附属医院消化病二科，新疆 乌鲁木齐 830011；2.新疆医科大学基础医学院病理生理学教研室，新疆 乌鲁木齐 830011

      卷次： 2023年34卷17期

      【摘要】 目的 系统评价基底浆细胞增多(BPC)预测溃疡性结肠炎(UC)复发风险的临床应用价值。方法 通过检索中国生物医学文献数据库、中国学术期刊网络出版总库、PudMed和EMbase等国内外权威数据库，全面收集相关的临床研究，按纳入排除标准筛选文献并收集相关数据和信息，采用STATA 16.0统计软件进行Meta分析，并对人数、研究类型、随访时间、内镜下缓解标准等进行亚组分析。结果 纳入10项研究，共计837例患者。BPC与复发风险的总体增加相关(OR=2.213，95%CI：1.323~3.700)；亚组分析结果显示，研究人数≥70人(OR 2.719，95%CI：1.796~4.119)、随访时间长(>12个月) (OR 2.408，95%CI：1.427~4.063)、内镜下缓解标准MES≤1 (OR 2.881，95%CI：1.842~4.506)均与较高的复发率有关。结论 在内镜缓解的UC患者中，BPC与较高的复发率相关，在临床中可将BPC作为预测UC复发的组织学特征。
      【关键词】 溃疡性结肠炎；组织学；基底浆细胞增多；复发；Meta分析
      【中图分类号】 R574.62 【文献标识码】 A 【文章编号】 1003—6350（2023）17—2553—06

Clinical value of basal plasmacytosis in predicting the recurrence risk of ulcerative colitis: a meta analysis.
CUIJia-wei 1, LI Xiu-juan 2, GAO Hong-liang 1, ZHANG Zhi-qiang 1. 1. Second Department of Gastroenterology, the FirstAffiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xingjiang, CHINA; 2. Department of Physiology andPathophysiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xingjiang, CHINA
【Abstract】 Objective To evaluate the clinical value of basal plasmacytosis (BPC) in predicting the recurrencerisk of ulcerative colitis (UC). Methods Relevant clinical studies were collected comprehensively from Chinese Bio-medical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), PudMed, EMbase, and otherdatabases, and the relevant data and information were selected according to the inclusion and exclusion criteria. Metaanalysis was carried out by STATA 16.0, and subgroup analyses were conducted through the number, research type, fol-low-up time, endoscopic remission criteria. Results A total of 837 patients were included in 10 the studies selected.BPC was associated with the overall increased risk of recurrence (OR=2.213, 95%CI 1.323-3.700). Subgroup analysisshowed that the number of people≥70 (OR 2.719, 95%CI 1.796-4.119), long follow-up (>12 months) (OR 2.408, 95%CI1.427-4.063), and endoscopic remission criteria MES≤1 (OR 2.881, 95%CI 1.842-4.506) were all associated with ahigher risk of recurrence. Conclusion In UC patients with endoscopic remission, BPC is associated with a higher recur-rence rate, and BPC can be used as a histological feature to predict the recurrence of UC in clinic.
      【Key words】 Ulcerative colitis; Histology; Basal plasmacytosis; Recurrence; Meta-analysis