标题：脑卒中患者血清VILIP-1、PRDX1、Pannexin1表达水平及其与预后的关系

      作者：郝井志 1，王瑞 2，刘晓琳 2    延安大学咸阳医院脑血管病研究所 1、检验科 2，陕西 咸阳 721000

      卷次： 2023年34卷12期

      【摘要】 目的 探讨脑卒中患者血清视锥蛋白样蛋白-1 (VILIP-1)、过氧化还原蛋白1 (PRDX1)、泛连接蛋白1(Pannexin1)的表达水平对预后的影响。方法 选取2020年1月至2022年 3月延安大学咸阳医院脑血管病研究所诊治的 110例脑卒中患者作为观察组，并选择同期我院 120例身体健康的体检者作为对照组，比较观察组与对照组，观察组不同病情、不同预后患者的血清VILIP-1、PRDX1、Pannexin1水平，并采用多因素Logistic回归分析影响脑卒中患者预后的危险因素。结果 观察组患者的VILIP-1、PRDX1、Pannexin1水平分别为(9.17±1.18) ng/mL、(9.30±1.83) ng/mL、(5.37±0.80) mg/mL，明显高于对照组的(3.10±0.60) ng/mL、(3.66±0.78) ng/mL、(2.02±0.61) mg/mL，差异均有统计学意义(P<0.05)；随着脑卒中患者病情的严重程度加重，血清VILIP-1、PRDX1、Pannexin1表达水平均逐渐升高，其中重度组明显高于中度和轻度组，中度组明显高于轻度组，差异均有统计学意义(P<0.05)；预后良好组患者的VILIP-1、PRDX1、Pannexin1水平分别为(4.69±0.81) ng/mL、(7.46±1.68) ng/mL、(4.95±1.13) mg/mL，明显低于预后不良组的(7.98±1.25) ng/mL、(12.01±1.93) ng/mL、(6.14±1.29) mg/mL，差异均有统计学意义(P<0.05)；预后良好组患者的高血压、糖尿病、冠心病、高同型半胱氨酸、高脂血症、吸烟、酗酒的发生率明显低于预后不良组，差异均有统计学意义(P<0.05)；经多因素Logistic回归性分析结果显示，血清VILIP-1、PRDX1、Pannexin1均是影响脑卒中患者预后的危险因素(P<0.05)。结论 脑卒中患者血清VILIP-1 、PRDX1、Pannexin1水平呈现高表达，且与病情和预后紧密相关，临床上检测血清VILIP-1、PRDX1、Pannexin1水平有助于评估患者的病情严重程度及预后情况。
      【关键词】 脑卒中；视锥蛋白样蛋白-1；过氧化还原蛋白1；泛连接蛋白1；预后；危险因素
      【中图分类号】 R743.3 【文献标识码】 A 【文章编号】 1003—6350（2023）12—1753—04

Expression levels of serum VILIP-1, PRDX1, and Pannexin1 in stroke patients and their relationship withprognosis.
HAO Jing-zhi 1, WANG Rui 2, LIU Xiao-lin 2. Institute of Cerebrovascular Disease 1, Clinical Laboratory 2, theXianyang Hospital of Yan'an University, Yan'an 721000, Shaanxi, CHINA
【Abstract】 Objective To investigate the expression and significance of serum cone opsin-like protein-1 (VIL-IP-1), peroxiredoxin 1 (PRDX1), and pannexin1 (Pannexin1) levels in stroke patients and their impact on prognosis.Methods A total of 110 cerebral stroke patients admitted to the Xianyang Hospital of Yan'an University from January2020 to March 2022 were selected as the observation group, and 120 healthy people in the hospital during the same peri-od were selected as the control group. The index levels of serum VILIP-1, PRDX1, and Pannexin1 were compared be-tween the observation group and the control group, and among patients with different conditions and between patientswith different prognosis in the observation group. Multivariate Logistic regression analysis was used to analyze the riskfactors of serum VILIP-1, PRDX1, and Pannexin1 on the prognosis of stroke patients. Results The levels of VILIP-1,PRDX1, and Pannexin1 in the observation group were (9.17±1.18) ng/mL, (9.30±1.83) ng/mL, and (5.37±0.80) mg/mL,which were significantly higher than (3.10±0.60) ng/mL, (3.66±0.78) ng/mL, (2.02±0.61) mg/mL in the control group(P<0.05). With the increase of the severity of cerebral stroke, the serum levels of ViliP-1, PRDX1, and Pannexin1 grad-ually increased; the serum levels of ViliP-1, PRDX1, and Pannexin1 were significantly higher in the severe group thanthe moderate and mild group, and in moderate group than mild group; the differences were statistically significant (P<0.05). The levels of VILIP-1, PRDX1, and Pannexin1 in the good prognosis group were (4.69±0.81) ng/mL, (7.46±1.68) ng/mL, and (4.95±1.13) mg/mL, which were significantly lower than (7.98±1.25) ng/mL, (12.01±1.93) ng/mL,(6.14±1.29) mg/mL in poor prognosis group (P<0.05). The incidence rates of hypertension, diabetes, coronary heartdisease, hyperhomocysteine, hyperlipidemia, smoking, and alcoholism in the good prognosis group were significantlylower than those in the poor prognosis group (P<0.05). Multivariate Logistic regression analysis showed that serumVILIP-1, PRDX1, and Pannexin1 were all risk factors affecting the prognosis of cerebral stroke patients (P<0.05).Conclusion The serum levels of VILIP-1, PRDX1, and Pannexin1 in cerebral stroke patients are highly expressed, andare closely related to the disease and prognosis. Clinical detection of serum levels of VILIP-1, PRDX1 and Pannexin1 ishelpful to evaluate the severity of the disease and prognosis of patients.
      【Key words】 Cerebral stroke; Cone-like protein-1; Peroxide-reduction protein 1; Pan-connexin 1; Prognosis;Risk factor