标题：沙丁胺醇对妊娠期子宫肌瘤红色变性患者血液流变学和血清VEGF水平的影响

      作者：苏彦梓 1，李联 2，庞妮 3    1.西安安琪儿妇产医院妇产科，陕西 西安 710077；2.西安凤城医院妇产科，陕西 西安 710000；3.长安医院妇产科，陕西 西安 710000

      卷次： 2023年34卷10期

      【摘要】 目的 探讨沙丁胺醇对妊娠期子宫肌瘤红色变性患者血液流变学、血清血管内皮生长因子(VEGF)水平的影响。方法 选择2020年1月至2022年4月西安安琪儿妇产医院妇产科收治的200例妊娠期子宫肌瘤红色变性患者纳入研究，按照随机数表法分为观察组和对照组各100例。在常规治疗基础上，对照组患者给予硫酸镁注射液治疗，直至宫缩消失24 h后停药，观察组患者在对照组治疗的基础上联合沙丁胺醇片治疗，直至患者腹痛消失4 d后停药。比较两组患者症状改善时间，治疗前、治疗7 d后的血液流变学指标(全血高切黏度、全血低切黏度)、血清VEGF水平的变化，同时比较两组患者的不良妊娠结局及治疗期间不良反应发生情况。结果 治疗后，观察组患者的体温正常时间、宫缩消失时间、腹痛消失时间分别为(3.35±0.67) d、(1.56±0.30) d、(4.21±0.69) d，明显短于对照组的(4.63±0.81) d、(3.17±0.64) d、(5.52±0.94) d，差异均有统计学意义(P<0.05)；治疗后，观察组患者的全血高切黏度、全血低切黏度及血清VEGF水平分别为(2.98±0.31) mPa·s、(5.49±0.76) mPa·s、(113.23±19.56) ng/mL，明显低于对照组的(3.40±0.39) mPa·s、(6.01±0.83) mPa·s、(126.57±21.13) ng/mL，差异均有统计学意义(P<0.05)；观察组患者的不良妊娠结局总发生率和不良反应总发生率分别为10.00%，4.00%，明显低于对照组的22.00%，12.00%，差异均有统计学意义(P<0.05)。结论 沙丁胺醇在妊娠期子宫肌瘤红色变性患者中的应用，可有效改善血液流变学、降低血清VEGF表达水平。
      【关键词】 子宫肌瘤红色变性；妊娠；沙丁胺醇；硫酸镁；血液流变学；血清血管内皮生长因子
      【中图分类号】 R714.25 【文献标识码】 A 【文章编号】 1003—6350（2023）10—1428—04

Effect of salbutamol on hematrheology and serum vascular endothelial growth factor levels in patients with reddegeneration of uterine fibroids during pregnancy.
SU Yan-zi 1, LI Lian 2, PANG Ni 3. 1. Department of Obstetrics andGynecology, Xi'an Angel Women's and Children's Hospital, Xi'an 710077, Shaanxi, CHINA; 2. Department of Obstetrics andGynecology, Xi'an Fengcheng Hospital, Xi'an 710000, Shaanxi, CHINA; 3. Department of Obstetrics and Gynecology,Chang'an Hospital, Xi'an 710000, Shaanxi, CHINA
【Abstract】 Objective To explore the effect of salbutamol on hemorrheology and serum vascular endothelialgrowth factor (VEGF) levels in patients with red degeneration of uterine fibroids during pregnancy. Methods A total of200 pregnant women with red degeneration of uterine fibroids admitted to Department of Obstetrics and Gynecology,Xi'an Angel Women's and Children's Hospital from January 2020 to April 2022 were included in the study. They were di-vided into an observation group and a control group according to random number table, with 100 patients in each group.On the basis of routine treatment, the patients in the control group were treated with magnesium sulfate injection until 24hours after the disappearance of uterine contraction. The patients in the observation group were treated with salbutamoltablets on the basis of the control group until 4 days after the disappearance of abdominal pain. The symptom improve-ment time, the changes of hemorheology indexes (whole blood high shear viscosity and whole blood low shear viscosity)and serum VEGF levels were compared before treatment and at 7 days after treatment. The incidence of adverse pregnan-cy outcomes and adverse reactions during treatment were compared. Results After treatment, the normal time of bodytemperature, disappearance time of uterine contraction, disappearance time of abdominal pain in the observation groupwere (3.35±0.67) d, (1.56±0.30) d, (4.21±0.69) d, which were significantly shorter than (4.63±0.81) d, (3.17±0.64) d,(5.52±0.94) d in the control group (P<0.05). After treatment, whole blood high viscosity, whole blood low viscosity andserum VEGF levels in the observation group were (2.98±0.31) mPa·s, (5.49±0.76) mPa·s, (113.23±19.56) ng/mL, whichwere significantly lower than (3.40±0.39) mPa·s, (6.01±0.83) mPa·s, (126.57±21.13) ng/mL in the control group (P<0.05). The total incidence of adverse pregnancy outcomes and adverse reactions in the observation group were 10.00%and 4.00%, respectively, significantly lower than 22.00% and 12.00% in the control group (P<0.05). Conclusion Theapplication of salbutamol in patients with red degeneration of uterine fibroids during pregnancy can effectively improvehemorheology and reduce serum VEGF expression level.
      【Key words】 Red degeneration of uterine fibroids; Pregnancy; Salbutamol; Magnesium sulfate; Hemorheology;Serum vascular endothelial growth factor