标题：健脾和胃化浊汤剂联合西药治疗慢性萎缩性胃炎的疗效及对患者胃肠激素、氧化应激状况的影响

      作者：王敬斌 1，王淑娴 2，蔡英剑 1，陈卫红 2    安康市中医医院治未病科 1、肾病科 2，陕西 安康 725000

      卷次： 2023年34卷9期

      【摘要】 目的 探讨健脾和胃化浊汤剂联合西药治疗慢性萎缩性胃炎的疗效及对患者胃肠激素、氧化应激状况的影响。方法 选择2019年3月至2022年3月安康市中医医院收治的80例慢性萎缩性胃炎患者展开研究，按照随机数表法分为观察组与对照组各40例。对照组患者使用常规西药治疗，观察组患者在对照组治疗的基础上联合健脾和胃化浊汤剂治疗，两组患者均持续治疗3个月。比较两组患者治疗后的临床疗效以及治疗前后的胃肠激素[胃泌素(GAS)、胃动素(MTL)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)]的变化；并比较两组患者治疗期间的不良反应发生情况。结果 观察组患者的治疗总有效率为92.50%，明显高于对照组的72.50%，差异有统计学意义(P<0.05)；治疗后，两组患者的GAS水平均明显降低，MTL水平均明显升高，且观察组GAS为(45.62±6.83) pg/mL，明显低于对照组的(67.35±8.20) pg/mL，MTL为(351.06±41.27) pg/mL，明显高于对照组的(287.60±37.82) pg/mL，差异均有统计学意义(P<0.05)；治疗后，两组患者的MDA均明显降低，SOD、GSH-Px均明显升高，且观察组患者的MDA为(4.54±0.85) μmol/L，明显低于对照组的(5.30±0.63) μmol/L，SOD、GSH-Px分别为(110.34±14.75) U/mL、(87.18±11.01) U/L，明显高于对照组的(89.02±10.65) U/mL、(69.32±7.82) U/L，差异均有统计学意义(P<0.05)；治疗期间，观察组和对照组患者的不良反应总发生率分别为10.00%和7.50%，差异无统计学意义(P>0.05)。结论 健脾和胃化浊汤剂联合西药治疗慢性萎缩性胃炎能有助于调节患者的胃肠激素，减轻氧化应激反应，临床应用效果显著，具有临床应用价值。
      【关键词】 慢性萎缩性胃炎；健脾和胃化浊汤剂；兰索拉唑；胃肠激素；氧化应激；疗效
      【中图分类号】 R573.3 【文献标识码】 A 【文章编号】 1003—6350（2023）09—1229—04

Effect of Jianpi Hewei Huazhuo Decoction combined with western medicine in the treatment of chronic atrophicgastritis and its influence on gastrointestinal hormones and oxidative stress of patients.
WANG Jing-bin 1, WANGShu-xian 2, CAI Ying-jian 1, CHEN Wei-hong 2. Department of Preventive Treatment 1, Department of Nephrology 2, AnkangTraditional Chinese Medicine Hospital, Ankang 725000, Shaanxi, CHINA
【Abstract】 Objective To study the effect of Jianpi Hewei Huazhuo Decoction combined with western medi-cine in the treatment of chronic atrophic gastritis and its influence on gastrointestinal hormones and oxidative stress ofpatients. Methods A total of 80 patients with chronic atrophic gastritis admitted to Ankang Traditional Chinese Medi-cine Hospital from March 2019 to March 2022 were selected for the study. All patients were divided into an observationgroup and a control group according to random number table method, with 40 patients in each group. The patients in thecontrol group were treated with conventional western medicine, and the patients in the observation group were treatedwith Jianpi Hewei Huazhuo Decoction on the basis of the control group, continuously for 3 months in both groups. Theclinical efficacy after treatment and the changes of gastrointestinal hormone [gastrin (GAS), motilin (MTL)], oxidativestress index [malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX)] before andafter treatment were compared between the two groups. The incidence of adverse reactions during treatment was com-pared between the two groups. Results The total effective rate of treatment in the observation group was 92.50% ,which was significantly higher than 72.50% in the control group (P<0.05). After treatment, the GAS levels in the twogroups were significantly decreased, and the MTL levels were significantly increased; GAS in the observation group was(45.62 ±6.83) pg/mL, which was significantly lower than (67.35± 8.20) pg/mL in the control group, while MTL was(351.06±41.27) pg/mL, significantly higher than (287.60±37.82) pg/mL in the control group; the differences were statisti-cally significnat (P<0.05). After treatment, the MDA in the two groups were significantly decreased, and SOD andGSH-Px were significantly increased; MDA in the observation group was (4.54±0.85) μmol/L, significantly lower than(5.30±0.63) μmol/L in the control group, while SOD and GSH-Px were (110.34±14.75) U/mL and (87.18±11.01) U/L,significantly higher than (89.02±10.65) U/mL and (69.32±7.82) U/L in the control group; the differences were statistical-ly significnat (P<0.05). During treatment, the total incidence of adverse reactions in the observation group and the con-trol group was 10.00% and 7.50%, respectively, with no statistically significant difference (P>0.05). Conclusion JianpiHewei Huazhuo Decoction combined with western medicine in the treatment of chronic atrophic gastritis can help regu-late the gastrointestinal hormones of patients and reduce oxidative stress response, which has clinical promotion value.
      【Key words】 Chronic atrophic gastritis; Jianpi Hewei Huazhuo Decoction; Lansoprazole; Gastrointestinal hor-mones; Oxidative stress; Curative effect