标题：植物雌激素调控牙髓干细胞成骨分化的研究进展

      作者：刘梦达 1，2 综述 冯红超 1，2，闫明 2，3 审校    1.遵义医科大学口腔医学院，贵州 遵义 563000；2.贵阳市口腔医院，贵州 贵阳 550002；3.遵义医科大学，贵州 遵义 563000

      卷次： 2023年34卷8期

      【摘要】 近年来运用骨组织工程技术修复颌面部骨缺损成为口腔再生医学研究的热点。牙髓干细胞 (DPSCs)具备多向分化潜能和较好的自我更新能力，其成骨向分化能力可为骨组织工程提供新的思路。植物雌激素是一类可发挥雌激素样作用的非甾体类化合物，研究发现植物雌激素可作为上调干细胞成骨向分化的天然诱导剂，在促进DPSCs成骨分化方面也具有重要作用。本文就目前植物雌激素调控DPSCs成骨分化的研究进展做一综述。
      【关键词】 牙髓干细胞；植物雌激素；成骨分化；骨缺损；研究进展
      【中图分类号】 R78 【文献标识码】 A 【文章编号】 1003—6350（2023）08—1195—06

Research progress on osteogenic differentiation of dental pulp stem cells regulated by phytoestrogens.
LIUMeng-da 1, 2, FENG Hong-chao 1, 2, YAN Ming 2, 3. 1. School of Oral Medicine, Zunyi Medical University, Zunyi 563000,Guizhou, CHINA; 2. Guiyang Stomatological Hospital, Guiyang 550002, Guizhou, CHINA; 3. Zunyi Medical University,Zunyi 563000, Guizhou, CHINA【Abstract】 In recent years, the use of bone tissue engineering technology to repair maxillofacial bone defectshas become the focus of oral regenerative medicine research. Dental pulp stem cells (DPSCs) have multi-directional dif-ferentiation potential and good self-renewal ability, and their osteogenic differentiation ability can provide new ideas forbone tissue engineering. Phytoestrogens are a class of non-steroidal compounds that can exert estrogen-like effects. Stud-ies have found that phytoestrogens can be used as a natural inducer to up-regulate osteogenic differentiation of stem cellsand also play an important role in promoting osteogenic differentiation of DPSCs. This article reviews the research prog-ress in the regulation of osteogenic differentiation of DPSCs by phytoestrogens.
      【Key words】 Dental pulp stem cells; Phytoestrogen; Osteogenic differentiation; Bone defect; Research progress