标题：BMP-2在骨骼生长发育中的作用及研究进展

      作者：郑潇飞 综述 程姣，罗祥友，蒋练 审校    遵义医科大学附属口腔医院，贵州 遵义 563000

      卷次： 2023年34卷7期

      【摘要】 骨形态发生蛋白(BMPs)是一类多功能的生长因子，属于转化生长因子-β (TGF-β)超家族，其在心脏、神经、软骨的形成以及成骨等发育过程中都是必不可少的。而骨形态发生蛋白 2 (BMP-2)作为第一个被发现的BMP，近年来已被广泛研究，其在骨骼发育、成年后骨形成与改建过程中发挥着关键性作用。本文就BMP-2的结构与功能、其激活和调节的信号通路、临床应用和并发症等方面做一综述，旨在为基础研究和临床治疗提供帮助。
      【关键词】 成骨；发育；骨形态发生蛋白2；转化生长因子-β信号通路；Wnt信号通路；临床应用
      【中图分类号】 R681 【文献标识码】 A 【文章编号】 1003—6350（2023）07—1047—05

Role and research progress of bone morphogenetic protein 2 in bone growth and development.
ZHENG Xiao-fei,CHENG Jiao, LUO Xiang-you, JIANG Lian. The Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi563000, Guizhou, CHINA【Abstract】 Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transform-ing growth factor β (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardio-genesis, neurogenesis, chondrogenesis, and osteogenesis. Bone morphogenetic protein-2 (BMP-2), as the first BMP discov-ered, has been extensively studied in recent years. It plays a key role in the process of skeletal development, bone formationand remodeling in adulthood. This article reviews the structure and function of BMP-2, its activation and regulation signal-ing pathways, and clinical applications and complications, in order to provide help for clinical treatment and basic research.
      【Key words】 Osteogenesis; Development; Bone morphogenetic protein-2; TGF-β signaling pathway; Wnt sig-naling pathway; Clinical application