标题：先天性心脏病患儿氨基末端脑钠素原与肺动脉高压的关系

      作者：李 雄 1，阳明玉 1，秦静庭 1，林 毅 2，王 丹 1，王长英 1
    (桂林医学院附属医院儿科 1，B超室 2，广西 桂林 541001)

      卷次： 2012年23卷1期

      【摘要】 目的 探讨氨基末端脑钠素原(NT-proBNP)与小儿先天性心脏病并肺动脉高压 (脉高压)的关
系。方法 应用酶联免疫吸附测定法(ELISA)检测 20例健康儿童(正常对照组)及 46例先天性心脏病患儿血浆
NT-proBNP浓度。用彩色多普勒超声心动图估测先天性心脏病患儿肺动脉压力，分为三组：无肺高压组18例、轻度
肺高压组18例、中重度肺高压组10例。结果 先天性心脏病无肺高压组NT-proBNP水平稍高于正常对照组，但差异
无统计学意义(P>0.05)。先心病患儿血浆NT-proBNP随着肺动脉压升高而明显升高，差异有统计学意义(P<0.01）。
结论 先心病合并肺动脉高压患儿血浆NT-proBNP浓度升高，升高程度与肺动脉压呈正相关，血浆NT-proBNP检测
对先天性心脏病合并肺高压具有特异的诊断价值，可作为先心病肺动脉高压评价的一个客观指标。

      【关键词】 先天性心脏病；氨基末端脑钠素原；肺动脉高压

      【中图分类号】 R725.4 【文献标识码】 A 【文章编号】 1003—6350（2012）01—084—02<

br>Relationship of serum N-terminal pro-brain natriuretic peptide and pulmonary artery pressure in pediatric
patients with congenital heart disease.
LI Xiong 1, YANG Ming-yu 1, QIN Jing-ting 1, LIN Yi 2, WANG Dan 1, WANG
Chang-ying 1. Department of Pediatrics 1, B Ultrasound Room 2, the Affiliated Hospital of Guilin Medical College, Guilin
541001, Guangxi, CHINA

【Abstract】 Objective To study the relationship of the serum level of N-terminal pro-brain natriuretic peptide
(proBNP) and pulmonary artery pressure in pediatric patients with congenital heart disease (CHD) complicated by pulmo-
nary artery hypertension (PAH). Methods The serum levels of NT-proBNP were detected with enzyme-linked immuno-
sorbent assay (ELISA) in 20 healthy children (the control group) and 46 children with CHD. The 46 children were estimat-
ed for pulmonary pressure by Doppler ultrasonography cardiogram and divided into three groups: group A (n=18, without
PAH), group B (n=18, with mild PAH), group C (n=10, with moderate to severe PAH). Results The levels of NT-proB-
NP in group A were slightly higher than those in the control group, with no statistically significant difference (P>0.05)
The NT-proBNP level in children with CHD significantly increased as the pulmonary pressure increased (P<0.01).
Conclusion There is arising tendency of NT-proBNP level in children with CHD and PAH. Detection of serum
NT-proBNP level has great value in the diagnosis of CHD complicated by PAH.

      【Key words】 Congenital heart disease; N-terminal pro-brain natriuretic peptide; Pulmonary hypertension
基金项目：广西壮族自治区卫生厅课题资助项目(编号：Z2011175)
作者简介：李 雄(1963—)，男，广西桂平县人，副主任医师，硕士。
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