标题：常规分次放疗联合同步化疗治疗中晚期鼻咽癌预后危险因素分析

      作者：孔 飞，蔡白振，陈显钊，张 坚，王一鸣，符 强，林少民，陈俊民，何钟麟，张欣欣
    (海南省人民医院放疗科，海南 海口 570311)

      卷次： 2012年23卷1期

      【摘要】 目的 探讨中晚期鼻咽癌常规分次放疗联合同步化疗患者预后的风险因素。方法 选择我院
2006年 01~12月常规分次放疗联合化疗的中晚期鼻咽癌患者临床资料 100例，将患者一般资料、临床资料及影
像学资料列为研究因素，建立COX生存风险比例模型，分析影响患者生存的相关因素及风险因素。结果 单
因素筛选结果显示：肿瘤分期、侵犯器官数目、规律放疗与否、规律化疗与否、早期复发是影响预后的相关因素。
COX分析结果显示：规律放疗与否、规律化疗与否、早期复发及肿瘤侵犯器官数目是常规分次放疗联合同步化疗
中晚期鼻咽癌患生存风险因素。结论 中晚期鼻咽癌常规分次放疗联合同步化疗患者的预后与肿瘤的进展及
放化疗的实施情况相关，应加强早期诊断及规律治疗。

      【关键词】 鼻咽癌；常规分次放疗；肿瘤分期；同步化疗

      【中图分类号】 R739.63 【文献标识码】 A 【文章编号】 1003—6350（2012）01—075—03<

br>Analysis on the risk factors of the prognosis of metaphase and advanced nasopharyngeal carcinoma with radio-
therapy and homeochronous chemotherapy.
KONG Fei, CAI Bai-zhen, CHEN Xian-zhao, ZHANG Jian, WANG
Yi-ming, FU Qiang, LIN Shao-min, CHEN Jun-min, HE Zhong-lin, ZHANG Xin-xin. Department of Radiation, Peo-
ple's Hospital of Hainan Province, Haikou 570311, Hainan, CHINA

【Abstract】 Objective To investigate the risk factors of the prognosis of metaphase and advanced nasopha-
ryngeal carcinoma with emphasize radiotherapy and homeochronous chemotherapy. Methods The clinical data of
100 patients with metaphase and advanced nasopharyngeal carcinoma who received radiotherapy combined with ho-
meochronous chemotherapy from Jan. 2006 to Dec. 2006 were analyzed. General information, clinical data, and imag-
ing date were classified as the investigative factor. COX model of survival were established, and the related factors
and risk factors for survival were analyzed. Results Univariate analysis showed that stage of tumor, number of infil-
trated organ, disciplinary radiotherapy or not, regular chemotherapy or not, and pristine relapse were the related fac-
tors of the prognosis. Cox & apos showed that number of infiltrated organ, disciplinary radiotherapy or not, regular
chemotherapy or not, and pristine relapse were the independent risk factors for prognosis. Conclusion The prognosis
of metaphase and advanced nasopharyngeal carcinoma with radiotherapy combined homeochronous chemotherapy
was corelated to tumor progression and the implement of radiotherapy combined chemotherapy. Early diagnosis and
regular treatment should were reinforced.

      【Key words】 Nasopharyngeal carcinoma; Conventional fractionated radiotherapy; Stage of tumor; Homeochro-
nous chemotherapy
基金项目：2005年度海南省自然科学基金指导项目(编号：805102)