标题：巨噬细胞迁移抑制因子与肿瘤关系的研究进展

      作者：白建荣 1，郑阿秀 1综述 罗泊涛 1，揭伟 1，2，3 审校    1.广东医科大学第一附属医院病理诊断与研究中心，广东 湛江 524023；2.海南医学院第一附属医院肿瘤内科，海南 海口 570102；3.海南医学院肿瘤研究所，海南 海口 571199

      卷次： 2023年34卷2期

      【摘要】 巨噬细胞迁移抑制因子(MIF)作为一种多效性细胞因子和宿主免疫的调节分子，在机体免疫和疾病中发挥重要作用。MIF具有癌基因特性，其高表达可促进癌细胞存活、增殖、迁移、侵袭、转移、血管生成并抑制凋亡。MIF与抗肿瘤免疫密切相关，基于MIF为靶点的特异性抑制剂目前尚未得到广泛应用。本文就MIF在肿瘤发生和进展中的作用、机制、治疗靶点等方面的研究进展进行综述，展望基于MIF为靶点的抑制剂运用在肿瘤防治中的意义。
      【关键词】 巨噬细胞迁移抑制因子；肿瘤；免疫；靶向治疗；抑制剂
      【中图分类号】 R730.1 【文献标识码】 A 【文章编号】 1003—6350（2023）02—0285—06

Research progress of the relationship between macrophage migration inhibitory factor and tumor.
BAI Jian-rong 1,ZHENG A-xiu 1, LUO Bo-tao 1, JIE Wei 1,2,3. 1. Pathological Diagnosis and Research Center, the First Affiliated Hospital ofGuangdong Medical University, Zhanjiang 524023, Guangdong, CHINA; 2. Department of Oncology, the First AffiliatedHospital of Hainan Medical University, Haikou 570102, Hainan, CHINA; 3. Cancer Institute, Hainan Medical University,Haikou 571199, Hainan, CHINA【Abstract】 Macrophage migration inhibitory factor (MIF), as a multipotent cytokine and regulatory molecule ofhost immunity, plays an important role in immunity and disease. MIF possesses the characteristics of oncogene, and MIFoverexpression can promote cancer cell survival, proliferation, migration, invasion, metastasis, angiogenesis, and inhibitapoptosis. MIF is closely related to anti-tumor immunity. At present, the inhibitors specific for MIF have not been widelyused. This article summarizes the research progress on the contribution, mechanism, and therapeutic targets of MIF in tu-morigenesis and progression, and looks forward to the significance of the application of inhibitors based on MIF in tu-mor prevention and treatment.
      【Key words】 Macrophage migration inhibitory factor; Tumor; Immune; Targeted therapy, Inhibitor　 ·综述·doi:10.3969/j.issn.1003-6350.2023.02.032基金项目：广东省“扬帆计划”高层次人才项目(编号：4YF16007G)。第一作者：白建荣(1997—)，女，硕士在读，主要从事肿瘤病理学研究。