标题：基于数据挖掘探讨金水相生法治疗肺肾气虚型COPD的用药规律

      作者：赵榕 1，汪奎 1，王娟 1，谢鑫 2，牛彩琴 2    1.川北医学院，四川 南充 637000；2.川北医学院附属医院中医科，四川 南充 637000

      卷次： 2023年34卷2期

      【摘要】 目的 挖掘肺肾气虚型慢性阻塞性肺疾病(COPD)的组方规律，为临床遣方用药及新药研发提供一定的理论依据。方法 以中国知识资源总库(CNKI)中2000—2020年有关中医药治疗肺肾气虚型COPD的文献为主要数据来源，借助中医传承计算平台(V3.0)进行频次统计、关联规则分析、熵聚类分析等。结果 根据纳排标准筛选出274篇临床文献，收录方剂共211首。使用高频次药物为黄芪、熟地黄、党参、五味子、茯苓等。用药功效主要以补虚药、化痰止咳平喘药、利水渗湿药和活血化瘀药为主。药物性味以温平、甘苦辛较为集中；归经主要归肺、脾、肾经。常用药对有黄芪-熟地黄、五味子-黄芪、茯苓-黄芪、党参-黄芪等。经关联规则与熵聚类数据分析，得出潜在新方4首。结论 肺肾气虚型COPD患者，中医药治疗以补肺益肾、纳气平喘为主，兼化痰健脾、活血化瘀；核心组合和新方具有重要的临床指导意义，值得临床推广。
      【关键词】 慢性阻塞性肺疾病；肺肾气虚型；金水相生法；中医药；数据挖掘；用药规律
      【中图分类号】 R563 【文献标识码】 A 【文章编号】 1003—6350（2023）02—0248—06

Medication rules of mutual generation between metal and water in the treatment of chronic obstructivepulmonary disease of lung and kidney Qi deficiency syndrome based on data mining.
ZHAO Rong 1, WANG Kui 1,WANG Juan 1, XIE Xin 2, NIU Cai-qin 2. 1.North Sichuan Medical College, Nanchong 637000, Sichuan, CHINA; 2.Department of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000,Sichuan, CHINA
【Abstract】 Objective To explore the medication rules for chronic obstructive pulmonary disease (COPD) oflung and kidney Qi deficiency syndrome, so as to provide a certain theoretical basis for clinical prescription and newdrug research and development. Methods The data were mainly from the clinical research using traditional Chinesemedicine (TCM) in the treatment of COPD of lung and kidney Qi deficiency syndrome in the China National KnowledgeInternet (CNKI) from 2000 to 2020. With the help of Traditional Chinese Medicine Inheritance Platform (V3.0), frequencystatistics, association rule analysis and systematic clustering were performed. Results Based on the inclusion and exclu-sion criteria, 274 clinical articles were selected and 211 prescriptions were included. The high-frequency drugs used weremainly Astragalus membranaceus, Rehmannia glutinosa, Codonopsis pilosula, Schisandra chinensis, and Poria cocos. Ac-cording to the classification of pharmacological effect, the drugs for tonifying deficiency, dispelling phlegm, relievingcough and preventing asthma, clearing damp and promoting diuresis, as well as promoting blood circulation and remov-ing blood stasis were concentrated. The drugs were mostly mild in nature and sweet, bitter and pungent in taste. The me-ridian tropism of the drugs was mainly concentrated in the meridians of the lung, spleen and kidney. Commonly useddrug combinations included Astragalus membranaceus-Rehmannia glutinosa, Schisandra chinensis-Astragalus membrana-ceus, Poria cocos-Astragalus membranaceus, Codonopsis pilosula-Astragalus membranaceus. The analysis of associationrules and entropy clustering data showed that 4 potential new prescriptions were obtained. Conclusion For patientswith COPD of lung and kidney Qi deficiency syndrome, TCM treatment mainly focuses on tonifying the lung and kid-ney as well as receiving Qi and relieving asthma, followed by resolving phlegm and strengthening spleen, promotingblood circulation and removing blood stasis. The core combinations and new prescriptions have important clinical guid-ing significance and are worthy of clinical promotion.
      【Key words】 Chronic obstructive pulmonary disease (COPD); Lung and kidney Qi deficiency syndrome; Mutualgeneration between metal and water; Traditional Chinese medicine; Data mining; Medication rules