标题：UGP2基因与肿瘤关系的研究进展

      作者：杨月娥 综述 周宇审校    广东医科大学附属医院消化内科，广东 湛江 524000

      卷次： 2023年34卷1期

      【摘要】 UDP-葡萄糖焦磷酸化酶2(UGP2)在糖代谢特别是糖原生物合成过程中起重要作用，其将葡萄糖部分从1磷酸葡萄糖转移到MgUTP，生成UDP葡萄糖并释放焦磷酸盐PPi。研究表明，UGP2基因与多种肿瘤关系密切。本文对UGP2基因与肿瘤的关系研究进展做一综述。
      【关键词】 尿苷二磷酸葡萄糖焦磷酸化酶2；消化道肿瘤；乳腺癌；白血病；甲状腺乳头状癌；肿瘤的靶向治疗
      【中图分类号】 R73 【文献标识码】 A 【文章编号】 1003—6350（2023）01—0145—04

Research progress on the relationship between uridine diphosphate-glucose pyrophosphorylase 2 and neoplasticdiseases.
YANG Yue-e, ZHOU Yu. Department of Gastroenterology, the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000, Guangdong, CHINA【Abstract】 Uridine diphosphate-glucose pyrophosphorylase 2 (UGP2) plays an important role in glucose metab-olism, especially glycogen biosynthesis, by transferring the glucose fraction from glucose 1 phosphate to MgUTP, gener-ating UDP glucose and releasing pyrophosphate PPi. Studies have shown that the UGP2 gene is closely related to a vari-ety of tumors. In this paper, we review the progress of research on the relationship between UGP2 gene and tumors.
      【Key words】 Uridine diphosphate-glucose pyrophosphorylase 2; Digestive tract tumor; Breast Cancer; Leukae-mia; Papillary thyroid carcinoma; Targeted therapy for tumor　　　·综述·doi:10.3969/j.issn.1003-6350.2023.01.033第一作者：杨月娥(1997—)，女，在读硕士研究生，主要研究方向为消化道肿瘤。