标题：糖尿病肾病足细胞损伤病理机制及信号通路的研究进展

      作者：王晨曦 1 综述 王子瑞 1，俞澜 2 审校    1.西北民族大学，甘肃 兰州 730000；2.甘肃省第二人民医院，甘肃 兰州 730000

      卷次： 2023年34卷1期

      【摘要】 糖尿病肾病(DN)是糖尿病最常见的微血管并发症，是终末期肾病的重要的病因之一。关于DN发病机制，最新研究发现，足细胞损伤在DN的病程中起到至关重要的作用，主要包括足细胞肥大、上皮间充质转化(EMT)、足细胞凋亡和足细胞自噬，且多个肾脏信号通路的破坏在这些病理损伤的进展中至关重要，例如腺苷单磷酸活化激酶信号通路(AMPK)、Wnt/β-catenin信号通路、内质网应激相关信号通路等。本文从糖尿病肾病足细胞损伤病理机制及信号通路的研究进展作为出发点，进一步了解分子机制方面糖尿病肾病足细胞损伤。
      【关键词】 糖尿病肾病；足细胞损伤；自噬；凋亡；信号通路
      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2023）01—0130—06

Research progress in pathological mechanism and related signaling pathways of podocyte injury in diabeticnephropathy.
WANG Chen-xi 1, WANG Zi-rui 1, YU Lan 2. 1. Northwest Minzu University, Lanzhou 730000, Gansu, CHINA;2. Gansu Second People's Hospital, Lanzhou 730000, Gansu, CHINA【Abstract】 Diabetic nephropathy (DN) is the most common microvascular complication of diabetes and one ofthe important causes of end-stage renal disease. Regarding the pathogenesis of DN, more and more scholars have recent-ly found that podocyte injury plays a crucial role in the course of DN, including podocyte hypertrophy, epithelial-mesen-chymal transition (EMT), podocyte apoptosis, and podocyte autophagy, and disruption of multiple renal signaling path-ways are critical in the progression of these pathological lesions, such as adenosine monophosphate-activated kinase sig-naling (AMPK), Wnt/β-catenin signaling, endoplasmic Network stress-related signaling pathways. This article aims tofurther understand the molecular mechanism of podocyte injury in diabetic nephropathy from the research progress inthe pathological mechanism and signaling pathway of podocyte injury in diabetic nephropathy.
      【Key words】 Diabetic nephropathy; Podocyte injury; Autophagy; Apoptosis; Signal pathway　　　·综述·doi:10.3969/j.issn.1003-6350.2023.01.030基金项目：中央高校青年教师创新项目(编号：31920210049)。第一作者：王晨曦(1997—)，女，住院医师，主要研究方向为肠道微生物和糖代谢研究。