标题：间充质干细胞治疗单倍体造血干细胞移植后

      作者：胃肠道重度GVHD一例并文献复习    张杉杉 1，2，张茜 1，21.甘肃中医药大学第一临床医学院，甘肃 兰州 730000；2.中国人民解放军联勤保障部队第九四〇医院血液科，甘肃 兰州 730000

      卷次： 2023年34卷1期

      【摘要】 异基因造血干细胞移植(allo-HSCT)是目前治疗恶性血液疾病的主要方法，单倍体造血干细胞移植(haplo-HSCT)作为其中一种方法，可使多数患者明显获益，但易并发移植物抗宿主病(GVHD)。目前治疗GVHD的一线方案为糖皮质激素，但仍有部分患者对激素耐药，导致预后不佳。间充质干细胞(MSCs)是一种具有自我更新能力和多向分化能力的非造血干细胞，可调节多种免疫细胞，并在一定条件下发挥免疫抑制作用，对GVHD有良好的治疗作用。本文报道1例haplo-HSCT后并发重度胃肠道GVHD (GI-GVHD)的患者经MCSs治疗后痊愈，并进行文献复习，旨在为临床治疗激素耐药型重度GI-GVHD患者提供思路。
      【关键词】 间充质干细胞；单倍体；造血干细胞移植；胃肠道；移植物抗宿主病
      【中图分类号】 R552 【文献标识码】 D 【文章编号】 1003—6350（2023）01—0122—04

Mesenchymal stem cells for treatment of severe gastrointestinal graft-versus-host disease after haploidhematopoietic stem cell transplantation: a case report and literature review.
ZHANG Shan-shan 1,2, ZHANG Qian 1,2.1.The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, CHINA; 2. Department ofHematology, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou 730000, Gansu, CHINA【Abstract】 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the main method for the treatmentof hematological malignancies. Haploid hematopoietic stem cell transplantation (haplo-HSCT), as one of the methods,can bring significant benefits to most patients, but it is prone to be complicated by graft-versus-host disease (GVHD). Atpresent, glucocorticoids are the first-line regimen for the treatment of GVHD, but some patients are still resistant to hor-mones, resulting in poor prognosis. Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with self-renewalability and multidirectional differentiation ability, which can regulate a variety of immune cells and exert immunosup-pressive effects under certain conditions, and have a good therapeutic effect on GVHD. In this paper, a case of severegastrointestinal GVHD (GI-GVHD) after haplo-HSCT was reported and recovered after MCSs treatment, and the litera-ture was reviewed, aiming to provide ideas for clinical treatment of severe GI-GVHD patients with hormone resistance.
      【Key words】 Mesenchymal stem cells; Haploid; Hematopoietic stem celltransplantation; Thegastrointestinal;Graft-versus-host disease　　　·个案报道·doi:10.3969/j.issn.1003-6350.2023.01.028基金项目：甘肃省自然科学基金(编号：21JRIRA183)；联勤保障部队第九四〇医院基础和临床培育项目(编号：2021yxky042)。第一作者：张杉杉(1991—)，女，在读研究生，主要研究方向为血液系统疾病研究。