标题：驱动基因阳性非小细胞肺癌脑转移靶向治疗新进展

      作者：王美才 综述 杨志雄，吴爱兵 审校    广东医科大学，广东 湛江 524000

      卷次： 2022年33卷21期

      【摘要】 肺癌是胸部肿瘤中最常见的恶性肿瘤之一，分为小细胞肺癌和非小细胞肺癌，其中后者占肺癌的80%~85%。驱动基因阳性的非小细胞肺癌患者发生脑转移的概率更高，预后不佳，若得到有效的治疗，其中位生存时间也仅有4~12个月。随着精准分子靶向治疗时代的发展，靶向治疗在驱动基因阳性的非小细胞肺癌脑转移患者中逐渐成为人们研究的热点，并取得令人满意的结果。本文主要对驱动基因阳性非小细胞肺癌脑转移靶向治疗新进展作一综述。
      【关键词】 非小细胞肺癌；脑转移；驱动基因阳性；靶向治疗；进展
      【中图分类号】 R734.2 【文献标识码】 A 【文章编号】 1003—6350（2022）21—2842—07

Recent advances in targeted therapy for brain metastasis of driving gene-positive non-small cell lung cancer.WANG Mei-cai, YANG Zhi-xiong, WU Ai-bing.
Guangdong Medical University, Zhanjiang 524000, Guangdong, CHINA【Abstract】 Lung cancer is one of the most common malignant tumors in the chest, which is divided into smallcell lung cancer and non-small cell lung cancer, of which the latter accounts for 80% to 85% of lung cancer. Patientswith driving gene-positive non-small cell lung cancer have higher probability of brain metastasis and poor prognosis. Ifeffective treatment is given, the median survival time of the patients is only 4~12 months. With the development of theera of precise molecular targeted therapy, targeted therapy has gradually become the focus of research among patientswith brain metastasis of non-small cell lung cancer with positive driving genes, and achieved satisfactory results. This ar-ticle mainly reviews the new progress of targeted therapy for brain metastasis of non-small cell lung cancer with positivedriving gene.
      【Key words】 Non-small cell lung cancer; Brain metastasis; Driving gene-positive; Targeted therapy; Advances　　　·综述·doi:10.3969/j.issn.1003-6350.2022.21.033