标题：乙肝肝硬化患者血清HBV-DNA水平与肝功能、CEA及AFP水平的相关性

      作者：吴丹 1，张锡坚 2，陈伟 1    1.东莞市中医院检验科，广东 东莞 523000；2.东莞市南城医院检验科，广东 东莞 523071

      卷次： 2022年33卷21期

      【摘要】 目的 探讨乙肝肝硬化患者血清乙型肝炎病毒脱氧核糖核酸(HBV-DNA)水平与肝功能、癌胚抗原(CEA)及甲胎蛋白(AFP)水平的相关性。方法 回顾性分析2019年 5月至 2021年 5月东莞市中医院收治的 60例乙肝肝硬化患者的临床资料，根据HBV-DNA水平的不同分为对照组28例(1.0×103 IU/mL。结果 观察组患者的血清ALT、AST、CEA、AFP水平分别为(110.12±22.04) IU/L、(96.22±18.48) IU/L、(5.90±0.40) ng/mL、(430.60±31.28) ng/mL，明显高于对照组的(91.20±20.38) IU/L、(74.51±10.60) IU/L、(3.18±0.15) ng/mL、(368.32±27.04) ng/mL，TBIL水平为(39.90±8.51) μmol/L，明显低于对照组的(66.57±10.80) μmol/L，差异均有统计学意义(P<0.05)；经Pearson相关性分析结果显示，血清ALT、AST、CEA、AFP水平与HBV-DNA水平均呈正相关(r=0.721、0.518、0.424、0.705，P<0.05)，TBIL水平与HBV-DNA水平呈负相关(r=-0.369，P<0.05)。结论 乙肝肝硬化患者肝功能、CEA及AFP水平与血清HBV-DNA水平密切相关，对其检测有助于病情的评估和临床的治疗。
      【关键词】 乙肝肝硬化；乙型肝炎病毒脱氧核糖核酸；肝功能；癌胚抗原；甲胎蛋白
      【中图分类号】 R575.2 【文献标识码】 A 【文章编号】 1003—6350（2022）21—2815—03

Correlation between serum HBV-DNA levels and liver function, CEA, AFP levels in patients with hepatitis Bcirrhosis.
WU Dan 1, ZHANG Xi-jian 2, CHEN Wei 1. 1.Department of Laboratory, Dongguan Hospital of TraditionalChinese Medicine, Dongguan 523000, Guangdong, CHINA; 2. Department of Laboratory, Dongguan Nancheng Hospital,City, Dongguan 523071, Guangdong, CHINA
【Abstract】 Objective To investigate the correlation between serum hepatitis B virus deoxyribonucleic acid(HBV-DNA) and liver function, carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) in patients with hepatitis Bcirrhosis. Methods The clinical data of 60 patients with hepatitis B cirrhosis admitted to Dongguan Hospital of Tradi-tional Chinese Medicine from May 2019 to May 2021 were retrospectively analyzed. According to different levels ofHBV-DNA, the patients were divided into a control group (28 cases, 1.0×103 IU/mL. Results The serum ALT, AST, CEA, and AFP levels of patients in the obser-vation group were (110.12±22.04) IU/L, (96.22±18.48) IU/L, (5.90±0.40) ng/mL, (430.60±31.28) ng/mL, which weresignificantly higher than (91.20±20.38) IU/L, (74.51±10.60) IU/L, (3.18±0.15) ng/mL, (368.32±27.04) ng/mL in the con-trol group, and the TBIL level was (39.90± 8.51) μmol/L, significantly lower than (66.57±10.80) μmol/L in the controlgroup, with statistically significant differences (P<0.05). Pearson correlation analysis showed that serum ALT, AST,CEA, AFP levels were positively correlated with HBV-DNA levels (r=0.721, 0.518, 0.424, 0.705, P<0.05), and TBIL lev-el was negatively correlated with HBV-DNA level (r=-0.369, P<0.05). Conclusion The levels of liver function, CEA,and AFP in patients with hepatitis B cirrhosis are closely related to the level of serum HBV-DNA, and the detection ofthese levels is helpful for the evaluation of the disease and clinical treatment.
      【Key words】 Hepatitis B cirrhosis; Hepatitis B virus deoxyribonucleic acid; Liver function; Carcinoembryonicantigen; Alpha-fetoprotein　　　·短篇论著·doi:10.3969/j.issn.1003-6350.2022.21.025