标题：2型糖尿病合并脑梗塞与血清同型半胱氨酸的相关性

      作者：王洋 1，冯伟华 2，王家豫 1
    （泉州医学高等专科学校附属人民医院内二科 1、内分泌科 2，福建 泉州 362000）

      卷次： 2016年27卷1期

      【摘要】 目的 探讨2型糖尿病合并脑梗塞与血清同型半胱氨酸(Hcy)的关系。方法 选择58例2型糖尿病
合并脑梗塞患者纳入观察组，58例未合并脑梗塞者纳入对照组，比较两组患者的血清Hcy、颈动脉内膜中层厚度
(IMT)水平。结果 观察组患者血清Hcy及颈动脉 IMT均明显高于对照组，差异均有统计学意义(P<0.05)；血清
Hcy水平在2型糖尿病合并脑梗塞患者颈动脉 IMT正常组、IMT增厚组及斑块形成组患者中依次升高，差异均有统
计学意义(P<0.05)，且血清Hcy水平与颈动脉 IMT呈正相关(r=0.735，P<0.05)。结论 2型糖尿病合并脑梗塞患者
颈动脉血管粥样硬化情况较单纯糖尿病患者更为严重，Hcy参与糖尿病患者发生脑梗塞的进程。

      【关键词】 2型糖尿病；脑梗塞；同型半胱氨酸；颈动脉内膜中层厚度

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2016）01—0114—02


Relationship of serum homocysteine and cerebral infarction in patients with type 2 diabetes mellitus.
WANG Yang 1,
FENG Wei-hua 2, WANG Jia-yu 1. The Second Department of Medicine 1, Department of Endocrinology 2, People's Hospital
Affiliated to Quanzhou Medical College, Quanzhou 362000, Fujian, CHINA

【Abstract】 Objective To investigate the relationship between serum homocysteine (Hcy) and cerebral
infarction in patients with type 2 diabetes mellitus. Methods Fifty-eight patients with type 2 diabetes mellitus
and cerebral infarction were included into the observation group, and 58 patients without cerebral infarction were in-
cluded into the control group. The serum Hcy levels and carotid intima-media thickness (IMT) in the two groups were
compared. Results The serum Hcy and carotid IMT in the observation group were significantly higher than those in
the control group (P<0.05). The serum Hcy levels in patients of type 2 diabetes mellitus and cerebral infarction with
carotid IMT normal group, IMT thickening group and the plaque formation group were increased gradually, and the
differences were of statistically significant (P<0.05). Serum Hcy levels and carotid IMT was positively correlated
(r=0.735, P<0.05). Conclusion The carotid atherosclerosis is more serious in patients with type 2 diabetes mellitus
and cerebral infarction than simple diabetes, and the Hcy is involved in the process of cerebral infarction.

      【Key words】 Type 2 diabetes mellitus; Cerebral infarction; Homocysteine; Carotid intima-media thickness
·临床经验·
6350.2016.01.038