标题：IL-17在幽门螺旋杆菌感染相关消化道疾病中的作用

      作者：沈秉正 1，宋金春 1，彭燕 1，张玲莉 1，张帆 1，喻研 2
    (1.武汉大学人民医院药学部，湖北 武汉 430060；
2.华中科技大学同济医学院附属同济医院消化内科，湖北 武汉 430030)

      卷次： 2016年27卷1期

      【摘要】 幽门螺旋杆菌感染是诸如胃炎、胃溃疡、胃癌等各种消化道疾病的重要诱因且在感染过程中会产生
许多细胞因子。近年来的研究证明，白介素-17在感染的病理生理学以及免疫介导的消化系统疾病中扮演着重要
较色。幽门螺旋杆菌感染使患者胃黏膜中 IL-17增加，从而通过MAPK/ERK1/2信号通路的激活导致 IL-8的分泌
表达。IL-8可趋化中性粒细胞而促进炎症反应，调节性T细胞可抑制该炎症反应。目前，幽门螺旋杆菌诱发的炎
症反应的机制尚未被完全清楚，宿主和病原菌均可促进炎症反应，如细胞毒力相关基因A、空泡毒素A。白细胞介
素-1β (IL-1β)、IL-6、肿瘤坏死因子-α (TNF-α)、转化生长因子-β1、IL-17、IL-18、IL-21以及 IL-22均与幽门螺旋杆
菌诱发的胃黏膜炎症反应有关，但具体细节与炎症反的不同模式仍然不清楚。大量的研究表明 IL-17在急性及慢
性炎症进展过程中具有重要功能，本文就 IL-17在胃炎、胃溃疡及胃癌相关消化系统疾病中的作用进行了回顾。

      【关键词】 白介素-17；辅助性T细胞17；幽门螺旋杆菌；胃炎；消化性溃疡；胃癌

      【中图分类号】 R57 【文献标识码】 A 【文章编号】 1003—6350（2016）01—0100—04


Role of IL-17 in gastrointestinal diseases caused by Helicobacter Pylori-infection.
SHEN Bing-zheng 1, SONG
Jin-chun 1, PENG Yan 1, ZHANG Ling-li 1, ZHANG Fan 1, YU Yan 2. 1. Department of Pharmacy, Renmin Hospital of
Wuhan University, Wuhan 430060, Hubei, CHINA; 2. Department of Gastroenterology, Tongji Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, CHINA
【Abstract】 Helicobacter pylori infection is an important factor which is related to gastritis, gastric ulcer, gastric
cancer and other gastrointestinal diseases. In the process of infection, it can produce many cytokines. In recent years,
many researches have proved that the interleukin-17 (IL-17) plays an important role in pathophysiology of infection and
immune mediated gastrointestinal diseases. IL-17 increased in H. pylori infected patients with gastric mucosa. The activa-
tion of MAPK/ERK 1/2 signaling pathway may lead to the expression of IL-8, which is a chemotactic factor of neutro-
phils and promote inflammation. Regulatory T cells (Tregs) can suppress the inflammatory response. At present, the
mechanism of H. pylori induced inflammation has not yet been fully understood, and host and pathogen can both pro-
mote inflammation, such as cytotoxin associated gene A (cagA) and vac uolating cytotoxin A (vacA). IL-1 β, IL-6,
TNF-α, TGF-β1, IL-17, IL-18, IL-21 and IL-22 are related with gastric mucosal inflammation induced by H. pylori, but
many details and different models of inflammatory response are still not clear. A large number of studies have shown that
IL-17 has important function in the process of acute and chronic inflammation. In this paper, the relationship between
IL-17 and gastrointestinal diseases, such as gastritis, gastric ulcer and gastric cancer, has been reviewed.

      【Key words】 Interleukin-17; T helper cell 17; Helicobacter pylori; Gastritis; Peptic ulcers; Gastric cancer
6350.2016.01.033