标题：巨噬细胞在器官移植免疫排斥反应中的研究进展

      作者：罗登科 1 综述 王毅 1，2 审校    1.海南医学院第二附属医院器官移植科，海南 海口 570100；2.海南医学院移植医学研究所，海南 海口 570100

      卷次： 2022年33卷16期

      【摘要】 器官移植是治疗终末期器官衰竭的最佳医疗手段之一。器官移植外科技术的成熟及免疫抑制剂疗法的应用使得移植物的短期存活率达到了较高的水平，但长期存活率并不理想，其主要原因是移植免疫排斥反应。巨噬细胞具有高度的可塑性，在移植免疫排斥中既可以作为炎症的效应细胞促进免疫反应的发生，又可作为免疫调节细胞诱导机体形成免疫耐受，抑制免疫反应的应答。这使巨噬细胞在移植免疫排斥中起到重要作用。因此，巨噬细胞可以作为新的治疗靶点，有希望改善目前器官移植患者及移植物的长期存活现状。
      【关键词】 巨噬细胞；器官移植；排斥反应；免疫耐受；调节性巨噬细胞
      【中图分类号】 R62 【文献标识码】 A 【文章编号】 1003—6350（2022）16—2148—05

Research progress of macrophages in immune rejection of organ transplantation.
LUO Deng-ke 1, WANG Yi 1, 2.1. Department of Organ Transplantation, the Second Affiliated Hospital of Hainan Medical University, Haikou 570100,Hainan, CHINA; 2.The Transplantation Institute of Hainan Medical University, Haikou 570100, Hainan, CHINA【Abstract】 Organ transplantation is one of the best medical methods for end-stage organ failure. The maturity oforgan transplantation surgery and the application of immunosuppressant therapy have made the short-term survival rateof transplant reaching a higher level, but the long-term survival rate is not ideal, which is mainly due to transplantationimmune rejection. Macrophages have high plasticity, which can not only act as inflammatory effector cells to promotethe occurrence of immune response, but also act as immunoregulatory cells to induce the formation of immune toleranceand inhibit the response of immune response. This makes macrophages play an important role in transplantation immunerejection. Therefore, macrophages can be used as a new therapeutic target, which is hopeful to improve the long-term sur-vival status of organ transplant patients and grafts.
      【Key words】 Macrophages; Organ transplantation; Rejection; Immune tolerance; Regulatory macrophage　　　·综述·doi:10.3969/j.issn.1003-6350.2022.16.029基金项目：海南省科技厅重大科技计划项目(编号：ZDKT2019009)