标题：PCOS不孕症促排卵期间单侧AFC、血清性激素水平变化及临床意义

      作者：张微微 1，马剑霞 2，黄梦婵 2    1.深圳市宝安区福永人民医院新田社区健康服务中心妇科，广东 深圳 518103；2.深圳市宝安区福永人民医院妇科，广东 深圳 518103

      卷次： 2022年33卷16期

      【摘要】 目的 检测并分析多囊卵巢综合征(PCOS)不孕症促排卵期间单侧窦卵泡计数(AFC)、血清性激素水平的变化及临床意义。方法 选择2020年1~12月深圳市宝安区福永人民医院收治的54例PCOS不孕症患者作为研究组，另选择同期在上述医院体检的 50例健康女性作为对照组。促排卵结束后，比较两组受检者用药前及研究组不同用药时间的单侧AFC、睾酮(T)、黄体生成素(LH)、卵泡雌激素(FSH)水平。干预1年后，比较研究组妊娠与非妊娠患者的单侧AFC、T、LH、FSH水平。结果 用药前，研究组患者的单侧AFC、T、LH、FSH水平分别为(14.42±1.39)个、(0.72±0.10) mmol/L、(10.38±0.81) mLU/mL、(5.78±1.63) mLU/mL，明显高于对照组的(6.53±1.50)个、(0.38±0.09) mmol/L、(5.13±0.70) mLU/mL、(5.03±1.52) mLU/mL，差异均具有统计学意义(P<0.05)；用药前，研究组患者的AFC、T、LH水平明显高于用药 4 d后的(8.85±2.76)个、(0.60±0.17) mmol/L、(7.79±2.38) mLU/mL和注射hCG日的(8.39±2.52)个、(0.40±0.10) mmol/L、(6.36±2.15) mLU/mL，而用药前 FSH水平明显低于用药 4 d后的(7.05±1.33) mLU/mL和注射hCG日的(6.63±2.15) mLU/mL，差异均有统计学意义(P<0.05)；研究组妊娠患者的单侧AFC、T、LH、FSH水平分别为(10.93±2.37)个、(0.43±0.11) mmol/L、(4.21±1.24) mLU/mL、(4.69±1.36) mLU/mL，明显低于非妊娠患者的(16.92±2.29)个、(0.79±0.13) mmol/L、(12.36±1.27) mLU/mL、(7.18±1.39) mLU/mL，差异均有统计学意义(P<0.05)。结论 PCOS不孕症患者促排卵期间单侧AFC、血清性激素水平表现为动态变化，能够在一定程度上评估治疗反应性。
      【关键词】 多囊卵巢综合征；不孕症；单侧窦卵泡计数；睾酮；黄体生成素；性激素
      【中图分类号】 R711.75 【文献标识码】 A 【文章编号】 1003—6350（2022）16—2139—03

Changes and clinical significance of unilateral antral follicle count, serum sex hormone levels during ovulationinduction in patients with polycystic ovary syndrome infertility.
ZHANG Wei-wei 1, MA Jian-xia 2, HUANGMeng-chan 2. 1. Department of Gynecology, Xintian Community Health Service Center, Fuyong People's Hospital of Bao'anDistrict of Shenzhen, Shenzhen 518103, Guangdong, CHINA; 2. Department of Gynecology, Fuyong People's Hospital ofBao'an District of Shenzhen, Shenzhen 518103, Guangdong, CHINA
【Abstract】 Objective To detect and analyze the changes and clinical significance of unilateral antral folliclecount (AFC) and serum sex hormone levels during ovulation induction in patients with polycystic ovary syndrome(PCOS) infertility. Methods Fifty-four patients with PCOS infertility treated in Fuyong People's Hospital of Bao'anDistrict of Shenzhen from January 2020 to December 2020 were selected as the study group, and 50 healthy women whounderwent physical examination in the same period were selected as the control group. After ovulation induction, the uni-lateral AFC, testosterone (T), luteinizing hormone (LH), and follicular estrogen (FSH) levels were compared between thetwo groups before medication and at different medication time in the study group. One year after intervention, the unilat-eral AFC, T, LH, and FSH levels of pregnant and non-pregnant patients in the study group were compared. Results Be-fore medication, the unilateral AFC, T, LH, and FSH levels in the study group were 14.42±1.39, (0.72±0.10) mmol/L,(10.38±0.81) mLU/mL, (5.78±1.63) mLU/mL, which were significantly higher than 6.53±1.50, (0.38±0.09) mmol/L,(5.13±0.70) mLU/mL, (5.03±1.52) mLU/mL in the control group (P<0.05). The AFC, T, LH levels in the study group be-fore medication were significantly higher than 8.85±2.76, (0.60±0.17) mmol/L, (7.79±2.38) mLU/mL after 4 days ofmedication and 8.39±2.52, (0.40±0.10) mmol/L, (6.36±2.15) mLU/mL on the day of hCG injection, while the FSH levelbefore medication was significantly lower than (7.05±1.33) mLU/mL after 4 days of medication and (6.63±2.15) mLU/mLon the day of hCG injection (P<0.05). The unilateral AFC, T, LH, and FSH levels of pregnant patients in the studygroup were 10.93±2.37, (0.43±0.11) mmol/L, (4.21±1.24) mLU/mL, (4.69±1.36) mLU/mL, which were significantlylower than 16.92±2.29, (0.79±0.13) mmol/L, (12.36±1.27) mLU/mL, (7.18±1.39) mLU/mL in non-pregnant patients (P<0.05). Conclusion Unilateral AFC and serum sex hormone levels show dynamic changes during ovulation induction inpatients with PCOS infertility, which can evaluate treatment response to a certain extent.
      【Key words】 Polycystic ovary syndrome; Infertility; Unilateral antral follicle count; Testosterone; Luteinizinghormone; Sex hormone　　　·短篇论著·doi:10.3969/j.issn.1003-6350.2022.16.026基金项目：广东省深圳市宝安区科技计划项目(编号：2018JD198)