标题：黏膜相关淋巴组织介导的 IgA肾病发病机制及治疗进展

      作者：叶婷 综述 许勇芝 审校    广东医科大学附属医院肾病研究所，广东 湛江 524000

      卷次： 2022年33卷15期

      【摘要】 IgA肾病(IgAN)是世界上非常常见的原发性肾小球疾病，不同种族的患病率存在差异，其发病机制目前尚不明确，也无特异性治疗。近期研究表明 IgAN与黏膜免疫密切相关。本文对 IgAN黏膜发病机制的种族异质性及目前针对黏膜免疫的 IgAN治疗进行综述，重点阐述鼻咽相关淋巴组织(NALT)和肠黏膜相关淋巴组织(GALT)在 IgAN中发病机制的研究和相关治疗的新进展。
      【关键词】 IgA肾病；肠黏膜相关淋巴组织；鼻咽相关淋巴组织；发病机制；种族异质性
      【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350（2022）15—2016—05

Pathogenesis and treatment of mucosa-associated lymphoid tissue mediated IgA nephropathy.
YE Ting, XUYong-zhi. Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong,CHINA【Abstract】 IgA nephropathy (IgAN) is a very common primary glomerular disease in the world. The prevalencevaries among different ethnic groups. The pathogenesis of IgAN is still unclear and there is no specific treatment. Recentstudies have shown that IgAN is closely related to mucosal immunity. In this review, we reviewed the racial heterogene-ity of IgAN mucosal pathogenesis and the current IgAN treatment for mucosal immunity, with emphasis on the pathogen-esis of nasopharynx-associated lymphoid tissue (NALT) and gut-associated lymphoid tissue (GALT) in IgAN and thenew progress in related treatment.
      【Key words】 IgA nephropathy (IgAN); Gut-associated lymphoid tissue (GALT); Nasopharynx-associated lym-phoid tissue (NALT); Pathogenesis; Racial heterogeneity　　　·综述·doi:10.3969/j.issn.1003-6350.2022.15.030