标题：老年冠心病患者UA、LVMI、ABI、baPWV的变化及其与冠脉病变的相关性

      作者：凌振雄，李维会，龙伟东    吴川市人民医院心内一区，广东 吴川 524500

      卷次： 2022年33卷15期

      【摘要】 目的 探讨老年冠心病患者尿酸(UA)、左心室重量指数(LVMI)、踝臂指数(ABI)、肱踝脉搏波传导速度(baPWV)的变化及其与冠脉病变的相关性。方法 选择吴川市人民医院2020年2月至2021年2月收治的75例老年冠心病患者作为观察组，并选择同期于该院体检的 70例健康老年人作为对照组。比较两组受检者的UA、LVMI、ABI、baPWV，同时比较不同冠状动脉狭窄程度 (Gensini)积分患者的 UA、LVMI、ABI、baPWV，并采用Pearson相关分析法分析UA、LVMI、ABI、baPWV水平与Gensini积分的相关性。结果 观察组患者的UA、LVMI、ABI、baPWV分别为(428.49±63.01) μmol/L、(123.28±14.63) g/m2、1.18±0.26、(1 762.11±200.30) cm/s，明显高于对照组的(330.15±40.70) μmol/L、(102.45±11.29) g/m2、0.87±0.15、(1 250.30±120.74) cm/s，差异均有统计学意义(P<0.05)；Gensini积分≥30患者的UA、LVMI、ABI、baPWV分别为(446.37±70.12) μmol/L、(130.28±18.24) g/m2、(1.80±0.40)、(1 700.06±184.08) cm/s，明显高于Gensini积分<30患者的(390.09±33.25) μmol/L、(112.30±15.49) g/m2、1.02±0.11、(1 622.30±100.20) cm/s，差异均有统计学意义(P<0.05)；经Pearson相关分析结果显示，UA、LVMI、ABI、baPWV与Gensini积分均呈正相关(r=0.547、0.650、0.326、0.805，P<0.05)。结论 老年冠心病UA、LVMI、ABI、baPWV与冠脉病变密切相关，对其检测有助于病情的评估和指导临床治疗。
      【关键词】 老年；冠心病；尿酸；左心室重量指数；踝臂指数；肱踝脉搏波传导速度；冠脉病变；相关性
      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350（2022）15—1998—03

Changes of uric acid, left ventricular mass index, ankle brachial index and brachial ankle pulse wave velocity inelderly patients with coronary heart disease and their correlation with coronary artery disease.
LING Zhen-xiong,LI Wei-hui, LONG Wei-dong. The First Department of Cardiology, Wuchuan People's Hospital, Wuchuan 524500,Guangdong, CHINA
【Abstract】 Objective To study changes of uric acid (UA), left ventricular mass index (LVMI), ankle brachialindex (ABI), brachial ankle pulse wave velocity (baPWV) and their correlation with coronary artery disease in elderly pa-tients with coronary heart disease. Methods Seventy-five elderly patients with coronary heart disease admitted to Wu-chuan People's Hospital from February 2020 to February 2021 were selected as the observation group, and 70 healthy el-derly people received physical examination during the same period were selected as the control group. The levels ofUA, LVMI, ABI, and baPWV were compared between the two groups among patients with different degree of coro-nary artery stenosis (Gensini) scores. The correlation between UA, LVMI, ABI, and baPWV and Ginsini score was an-alyzed by Pearson correlation analysis. Results The UA, LVMI, ABI, and baPWV levels of the observation group were(428.49 ± 63.01) μmol/L, (123.28 ± 14.63) g/m2, 1.18 ± 0.26, (1 762.11 ± 200.30) cm/s, which were significantly higher(330.15± 40.70) μmol/L, (102.45±11.29) g/m2, 0.87±0.15, (1 250.30±120.74) cm/s of the control group (P<0.05). The UA,LVMI, ABI, and baPWV levels of patients with Gensini score ≥30 were (446.37±70.12) μmol/L, (130.28±18.24) g/m2,1.80±0.40, (1 700.06±184.08) cm/s, which were significantly higher than (390.09±33.25) μmol/L, (112.30±15.49) g/m2,1.02±0.11, (1 622.30±100.20) cm/s of patients with Gensini score <30 (P<0.05). Pearson correlation analysis showedthat UA, LVMI, ABI, baPWV were positively correlated with Gensini score (r=0.547, 0.650, 0.326, 0.805, P<0.05).Conclusion The levels of UA, LVMI, ABI, and baPWV in elderly patients with coronary artery disease are closely re-lated to coronary artery disease, and their detection is helpful for the evaluation and guiding clinical treatment of thedisease.
      【Key words】 Elderly; Coronary heart disease; Uric acid; Left ventricular mass index; Ankle brachial index; Bra-chial ankle pulse wave velocity; Coronary artery lesions; Correlation　　　·短篇论著·doi:10.3969/j.issn.1003-6350.2022.15.025