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      标题:动脉栓塞术联合胸腔镜肺叶切除术治疗肺结核伴大咯血的疗效及对患者肺功能、动脉血气的影响
      作者:黄大业 1,孟祥国 2,赵坚 1,郭琪 1    西安市胸科医院外科 1、结核合并症科 2,陕西 西安 710061
      卷次: 2022年33卷15期
      【摘要】 目的 探讨动脉栓塞术(AE)联合胸腔镜肺叶切除术(VATS)治疗肺结核伴大咯血的疗效及对患者肺功能、动脉血气的影响。方法 选择西安市胸科医院2019年9月至2021年5月收治的肺结核伴大咯血患者100例,采用随机数表法分为对照组和观察组各50例。对照组患者给予VATS治疗,观察组患者给予AE联合VATS治疗。比较两组患者的疗效,以及治疗前后的肺功能[用力肺活量(FVC)、1秒用力呼气容积(FEV1)、FEV1占 FVC比值(FEV1/FVC)]和动脉血气指标[pH值(pH)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]水平,并统计两组患者3个月内的复发率和死亡率。结果 观察组患者的治疗总有效率为94.00%,明显高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,两组患者的 FVC、FEV1、FEV1/FVC均较治疗前升高,且观察组分别为(86.32±5.88)%、(80.41±4.98)%、(78.41±5.21)%,明显高于对照组的(80.41±4.89)%、(75.41±5.09)%、(70.41±4.98)%,差异均有统计学意义(P<0.05);治疗后,两组患者的 PaO2较治疗前升高,且观察组为(13.31±1.31) kPa,明显高于对照组的(10.98±2.21) kPa,但PaCO2较治疗前降低,且观察组为(3.10±0.31) kPa,明显低于对照组的(3.98±0.28) kPa,差异均有统计学意义(P<0.05),而两组患者治疗后的 pH比较差异无统计学意义(P>0.05);随访 3个月,观察组患者的复发率为2.00%、死亡率为4.00%,明显低于对照组的16.00%、20.00%,差异均有统计学意义(P<0.05)。结论 AE联合VATS治疗肺结核伴大咯血可有效改善患者的肺功能及动脉血气指标,复发率、死亡率低,临床治疗效果理想,是一种安全有效的治疗方式。
      【关键词】 肺结核;大咯血;动脉栓塞术;胸腔镜肺叶切除术;肺功能;动脉血气
      【中图分类号】 R521 【文献标识码】 A 【文章编号】 1003—6350(2022)15—1931—04

Effect of arterial embolization combined with thoracoscopic lobectomy in the treatment of pulmonarytuberculosis with massive hemoptysis and its effect on pulmonary function and arterial blood gas.

HUANG Da-ye 1,MENG Xiang-guo 2, ZHAO Jian 1, GUO Qi 1. Department of Surgery 1, Department of Tuberculosis Complications 2, Xi'anChest Hospital, Xi'an 710061, Shaanxi, CHINA
【Abstract】 Objective To investigate the efficacy of arterial embolization (AE) combined with thoracoscopiclobectomy (VATS) in the treatment of pulmonary tuberculosis with massive hemoptysis and its effect on pulmonary func-tion and arterial blood gas. Methods A total of 100 patients with pulmonary tuberculosis with massive hemoptysistreated in Xi'an Chest Hospital from September 2019 to May 2021 were randomly divided into a control group and an ob-servation group. The patients in the control group were treated with VATS, and the patients in the observation groupwere treated with AE combined with VATS. The curative effects of the two groups were compared, as well as the levelsof pulmonary function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1 to FVC ratio(FEV1/FVC)] and arterial blood gas indexes [pH value (pH), arterial oxygen partial pressure (PaO2), arterial carbon diox-ide partial pressure (PaCO2)] before and after treatment. The recurrence rate and mortality of the two groups within 3   

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