标题：肿瘤归巢肽及其在肿瘤靶向治疗中的应用

      作者：吴娇 1，2，杨唐斌 2，柳长柏 1，2
    (1.三峡大学肿瘤微环境与免疫治疗湖北省重点实验室，湖北 宜昌 443002；
2.三峡大学医学院，湖北 宜昌 443002)

      卷次： 2016年27卷1期

      【摘要】 肿瘤归巢肽(THPs)是一类对肿瘤组织或血管具有归巢效应的多肽，它能识别和结合肿瘤组织或血管
表面的特异性受体或标志物。除了原位肿瘤，THPs还能识别并结合血管源性或转移性肿瘤。因此，THPs可将抗肿
瘤药物直接靶向递送至肿瘤组织、细胞中，能够减少或消除药物耐受及毒副作用。本文将综述迄今人们对THPs的
认识、开发及其在抗肿瘤诊断及治疗应用中所取得的进展。

      【关键词】 肿瘤归巢肽；靶向递送；抗肿瘤；靶向治疗

      【中图分类号】 R730.5 【文献标识码】 A 【文章编号】 1003—6350（2016）01—0082—03


Tumor homing peptides and their applications in tumor targeting therapy.
WU Jiao 1,2, YANG Tang-bin 2, LIU
Chang-bai 1,2. 1. Hubei Province Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges
University, Yichang 443002, Hubei, CHINA; 2. Medical School of China Three Gorges University, Yichang 443002, Hubei, CHINA
【Abstract】 Tumor homing peptides (THPs) are a kind of peptide which specifically bind to the tumor cells and
tumor vessels. THPs have ability to recognize and bind to primary tumor as well as metastatic tumors through the specif-
ic receptors or bio-markers on the surface of the tumor cells or tumor vessels. In consequence, THPs can be used as deliv-
ery tools for anti-tumor drugs targeted to tumor tissues and cells directly, which will be able to reduce or eliminate the
drug resistance and side effects. This review will summarize the development and applications of THPs in the tumor di-
agnosis and the anti-tumor therapies.

      【Key words】 Tumor homing peptides; Delivery vector; Anti-tumor; Targeted therapy
·综 述·
6350.2016.01.027