标题：ROS与脓毒症NLRP3活化的关系及其调控机制

      作者：韩雪妹 综述 王日兴 审校    海南医学院第二附属医院急诊科，海南 海口 570311

      卷次： 2022年33卷14期

      【摘要】 NLRP3是目前研究最为广泛的炎性体之一，并且是固有免疫的关键组分之一。在各种内外源性刺激因素作用下，核心蛋白NLRP3、连接蛋白ASC以及效应蛋白pro-caspase-1在胞质内组装成为NLRP3炎性体，形成具有催化活性的Caspase-1，后者将pro-IL-1β、pro-IL-18剪切成 IL-1β、IL-18并分泌至效应部位参与炎症反应的发生、发展过程。过度活化的NLRP3炎性体可致机体内产生过度的炎症反应，是导致脓毒症和多器官功能障碍的重要原因。目前对NLRP3炎性体活化的具体调控机制研究仍不完全，但是众多的研究表明，其激活的关键因素之一是活性氧(ROS)的产生。本文将着眼于探讨ROS在调控脓毒症NLRP3炎性体活化中的作用研究。
      【关键词】 脓毒症；炎性体；NLRP3炎性体；活性氧；线粒体
      【中图分类号】 R631 【文献标识码】 A 【文章编号】 1003—6350（2022）14—1871—04

Correlation of reactive oxygen species with NLRP3 inflammasome activation in sepsis and its mechanisms HANXue-mei, WANG Ri-xing.
Department of Emergency, the Second Affiliated Hospital of Hainan Medical University, Haikou570311, Hainan, CHINA【Abstract】 Nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome is one of themost widely studied inflammasome and one of the key components of innate immunity. Under the action of various exog-enous stimulus factors, the core protein NLRP3, apoptosis-like protein containing a caspase recruitment domain (ASC),and the cysteine aspartate specific protease-1 precursor (pro-caspase-1) are assembled into NLRP3 inflammasome incytoplasm, forming catalytic caspase-1, which cleaves interleukin 1β precursor (pro-IL-1β) and interleukin 18 precur-sor (pro-IL-18) into interleukin 1β (IL-1β) and interleukin 18 (IL-18). Excessive activation of NLRP3 inflammasomecan cause excessive inflammatory reaction in the body, which is an important cause of sepsis and multiple organ dys-function. At present, the research on the specific regulatory mechanism of NLRP3 inflammasome activation is still in-complete, but many studies have shown that one of the key factors of NLRP3 activation is the production of reactiveoxygen species (ROS). This article will focus on the role of ROS in regulating the activation of NLRP3 inflammasomein sepsis.
      【Key words】 Sepsis; Inflammasome; Nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) in-flammasome; Reactive oxygen species (ROS); Mitochondrial　　　·综述·doi:10.3969/j.issn.1003-6350.2022.14.028基金项目：海南省自然科学基金(编号：818MS148)