标题：深圳市未成年人干化学肾功能检测指标参考区间调查

      作者：罗小娟，马东礼，曹科，赖建威，刘新刚，陈运生，陈虹宇
    (深圳市儿童医院检验科，广东 深圳 518038)

      卷次： 2016年27卷1期

      【摘要】 目的 建立深圳市健康未成年人干化学血清尿素(Urea)、肌酐(Creatinine，Cr)、尿酸(Uric acid，UA)
的参考区间。方法 使用干化学分析系统检测 1 401例(男 760例，女 641例) 3个月~18周岁健康未成年人血清
标本，分析各年龄、性别组肾功能检测结果。结果 ① 7~12岁组的Urea、Cr，13~18岁组的Urea、Cr、UA男、女组
间检测结果比较差异均有统计学意义(P<0.05)，均为男童高于女童，其余项目男、女童间检测结果比较差异均无
统计学意义(P>0.05)；② 3种项目检测结果均随年龄的增长而增加，不同年龄组间检测结果比较差异均有统计
学意义(P<0.05)，其中 4~6岁组与 7~12岁组、7~12岁组与 13~18岁组的Urea检测结果比较差异均无统计学意义
(P>0.05)，其余各年龄间比较差异均有统计学意义(P<0.05)；③ Urea的参考区间为：3个月~3岁组1.3~6.1 mmol/L、
3~18岁组2.1~7.1 mmol/L，Cr的参考区间为：3个月~3岁组14.6~56.5 ?mol/L、4~6岁组27.2~52.5 ?mol/L、7~12岁组
27.5~60.1 ?mol/L、13~18岁男童组30.5~103.5 ?mol/L、13~18岁女童组29.2~88.6 ?mol/L，UA的参考区间为：3个月~
6岁组 144.6~378.5 ?mol/L、7~12岁组 165.5~429.9 ?mol/L、13~18岁男童组 185.9~465.7 ?mol/L、13~18岁女童组
159.9~429.1 ?mol/L。结论 建立起深圳地区健康未成年人干化学肾功能检测指标的参考区间。

      【关键词】 未成年人；干化学；肾功能；参考区间

      【中图分类号】 R446 【文献标识码】 A 【文章编号】 1003—6350（2016）01—0076—03


Investigation on reference intervals of kidney function tests among healthy children and adolescents based on dry
chemical system in Shenzhen.
LUO Xiao-juan, MA Dong-li, CAO Ke, LAI Jian-wei, LIU Xin-gang, CHEN Yun-sheng,
CHEN Hong-yu. Department of Clinical Laboratory, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, CHINA

【Abstract】 Objective To establish the reference intervals of urea, creatinine (Cr), uric acid (UA) on dry chemi-
cal system among healthy children and adolescents in Shenzhen. Methods A total of 1 401 blood samples from 760 male
and 641 female healthy children and adolescents aged from 3 months to 18 years were collected. Kidney function tests in
venous blood were detected by the VITROS 350 system, and data were analyzed by statistical methods. Results ① The
urea, Cr of 7~12 years old boys and urea, Cr, UA of 13~18 years old boys were significantly higher than those in girls
(P<0.05). The remaining items showed no significant differences between boys and girls (P>0.05). ② The reference in-
tervals of 3 items were increased with age, showing significant differences in different age groups (P<0.05). However,
urea showed no significant difference between 4~6 years group and 7~12 years group, as well as between 7~12 years
group and 13~18 years group. ③ The reference intervals of serum urea were 1.3~6.1 mmol/L for 3 months to 3 years
group, 2.1~7.1 mmol/L for 3~18 years group. The reference intervals of Cr were 14.6~56.5 μmol/L for 3 months to 3
years group, 27.2~52.5 μmol/L for 4~6 years group, 27.5~60.1 μmol/L for 7~12 years group, 30.5~103.5 μmol/L for
13~18 years group (male), and 29.2~88.6 μmol/L for 13~18 years group (female). The reference intervals of UA were
144.6~378.5 μmol/L for 3 months to 6 years group, 165.5~429.9 μmol/L for 7~12 years group, 185.9~465.7 μmol/L for
13~18 years group (male), and 159.9~429.1 μmol/L for 13~18 years group (female). Conclusion The reference inter-
vals of urea, Cr, UA were established on dry chemical system among healthy children and adolescents in Shenzhen.

      【Key words】 Children and adolescents; Dry chemical; Kidney function; Reference interval
·论 著·
6350.2016.01.025