标题：经鼻持续正压通气在毛细支气管炎合并呼吸衰竭患儿治疗中的应用

      作者：高晓敏，严晓华，王侠
    (陕西省人民医院儿科，陕西 西安 710068)

      卷次： 2016年27卷1期

      【摘要】 目的 观察经鼻持续正压通气(CPAP)辅助治疗毛细支气管炎合并呼吸衰竭患儿的临床效果。
方法 选取本院儿科自2014年1~12月收治的98例毛细支气管炎合并呼吸衰竭患儿，根据入院顺序分为观察组和
对照组各49例，两组患儿均给予解痉平喘、吸痰、抗感染、纠正电解质紊乱等治疗，观察组同时给予CPAP治疗，对
照组则给予经鼻导管吸氧治疗，比较两组患儿治疗后的血气指标、临床症状缓解时间及治疗效果。结果 治疗后
12 h、24 h，两组患儿的心率(HR)、血液酸碱度(pH)、动脉血二氧化碳分压(PaCO2)、血氧饱和度(SpO2)、动脉血氧分压
(PaO2)较治疗前均明显好转，差异均有统计学意义(P<0.05)，且观察组的上述指标均优于对照组，差异均有统计学意
义(P<0.05)；观察组紫绀消失时间、喘憋消失时间、心率恢复时间、哮鸣音消失时间和住院时间均明显短于对照组，
差异均有统计学意义(P<0.05)；治疗3 d后观察组的显效率为69.39%，明显高于对照组的48.98%，差异有统计学意
义(P<0.05)。结论 采用经鼻持续正压通气辅助治疗毛细支气管炎合并呼吸衰竭患儿能够缩短治疗时间，缓解患
儿的临床症状，提高临床治疗效果。

      【关键词】 经鼻持续正压通气；毛细支气管炎；呼吸衰竭；临床效果

      【中图分类号】 R725.6 【文献标识码】 A 【文章编号】 1003—6350（2016）01—0059—03


Application of continuous positive airway pressure in the treatment of children with bronchiolitis complicated by
respiratory failure.
GAO Xiao-min, YAN Xiao-hua, WANG Xia. Department of Pediatrics, People's Hospital of Shaanxi
Province, Xi'an 710068, Shaanxi, CHINA

【Abstract】 Objective To observe the clinical effect of nasal continuous positive airway pressure (CPAP) in
the treatment of children with bronchiolitis complicated by respiratory failure. Methods A total of 98 children with
bronchiolitis complicated by respiratory failure treated in our hospital from January 2014 to December 2014 were select-
ed, which were divided into observation group and control group according to the order of admission, each with 49 chil-
dren. The two groups were both given antispasmodic, suctioning, anti-infective treatment, as well as correction of elec-
trolyte imbalance. The observation group received CPAP therapy, while the control group was treated with nasal cannu-
la oxygen therapy. Blood gas indicators, clinical symptoms and treatment time were compared between the two groups.
Results 12 h, 24 h after treatment, heart rate (HR), blood acidity (pH), arterial carbon dioxide pressure (PaCO2), oxy-
gen saturation (SpO2), arterial oxygen tension (PaO2) in the two groups were all significantly improved compared with
those before treatment (P<0.05), and the indexes of the observation group were significantly better than those of the con-
trol group (P<0.05). The cyanosis disappeared time, shortness of breath disappeared time, heart rate recovery time,
wheezing disappeared time and length of hospital stay were significantly shorter in the observation group than the con-
trol group (P<0.05). The effective rate was 69.39% in the observation group 3 d after treatment, significantly higher than
48.98% in the control group (P<0.05). Conclusion Using nasal continuous positive airway pressure for adjunctive ther-
apy in children with bronchiolitis complicated by respiratory failure can shorten the treatment time, relieve symptoms,
and improve clinical outcomes.

      【Key words】 Nasal continuous positive pressure ventilation; Capillary bronchitis; Respiratory failure; Clinical effect
·论 著·
6350.2016.01.019