标题：乌灵胶囊联合星状神经节阻滞治疗焦虑性失眠疗效观察

      作者：卫琰 1，刘庆 1，朱震宏 2，陈弘 1，夏建华 1，张俊 1    上海市浦东新区人民医院疼痛科 1、神经内科 2，上海 201299

      卷次： 2022年33卷6期

      【摘要】 目的 观察乌灵胶囊联合星状神经节阻滞治疗焦虑性失眠的疗效。方法 选取2019年 1月 1日至2019年12月31日在上海市浦东新区人民医院神经内科门诊和疼痛科门诊就诊的焦虑性失眠患者60例，采用随机数表法将患者分为对照组和观察组，每组30例。对照组患者采用单纯口服乌灵胶囊治疗，观察组患者在对照组治疗的基础上再采用超声引导下星状神经节阻滞疗法治疗，疗程8周。治疗结束后，采用汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量指数量表(PSQI)评价两组患者的焦虑症状和睡眠质量，同时比较两组患者的治疗效果和治疗期间的不良反应发生情况。结果 观察组患者治疗 1周、2 周、4 周和 8周后的HAMA评分分别为(20.34±3.83)分、(16.65±2.58)分、(14.72±2.01)分、(12.66±1.58)分，明显低于对照组的(22.57±4.02)分、(19.46±2.87)分、(17.39±2.13)分、(15.39±2.21)分，差异均具有统计学意义(P< 0.05)；观察组患者治疗 1周、2 周、4 周和 8周后的 PSQI评分分别为(12.21±1.79)分、(9.77±1.35)分、(6.79±1.12)分、(5.08+1.19)分，明显低于对照组的(14.79±1.83)分、(12.70+1.69)分、(10.79±1.32)分、(9.49+1.74)分，差异均具有统计学意义(P<0.05)；治疗结束，观察组患者的治疗总有效率为86.67%，明显高于对照组60.00%，差异有统计学意义(P< 0.05)；两组患者治疗期间均未发生明显不良反应。结论 口服乌灵胶囊联合星状神经节阻滞应用于焦虑性失眠可以明显缓解患者的焦虑失眠等症状，且在治疗过程中无明显副作用，可在临床推广应用。
      【关键词】 焦虑性失眠；乌灵胶囊；超声；星状神经节阻滞；疗效
      【中图分类号】 R256.23 【文献标识码】 A 【文章编号】 1003—6350（2022）06—0732—04

Therapeutic effect of Wuling capsule combined with stellate ganglion block in the treatment of anxiety-inducedinsomnia.
WEI Yan 1, LIU Qing 1, ZHU Zhen-hong 2, CHEN Hong 1, XIA Jian-hua 1, ZHANG Jun 1. Department of Pain 1,Department of Neurology 2, Shanghai Pudong New Area People's Hospital, Shanghai 201299, CHINA
【Abstract】 Objective To explore the efficacy of Wuling capsule combined with stellate ganglion block in thetreatment of anxiety-induced insomnia. Methods A total of 60 patients with anxiety insomnia enrolled in the Depart-ment of Neurology and Department of Pain, Shanghai Pudong New Area People's Hospital from Jan. 1 to Dec. 31, 2019were selected. All patients were randomly divided into a control group and an observation group, with 30 patients ineach group. The control group was treated with oral Wuling capsule alone, and the observation group was treated withultrasound-guided stellate ganglion block therapy on the basis of the control group, for 8 weeks. After treatment, Hamil-ton Anxiety Scale (HAMA) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the anxiety symptomsand sleep quality of the two groups. At the same time, the effect of treatment and the occurrence of adverse reactions dur-ing treatment were compared between the two groups. Results The HAMA scores of the observation group at 1 week,2 weeks, 4 weeks and 8 weeks after treatment were (20.34±3.83) points, (16.65 ± 2.58) points, (14.72±2.01) points, and(12.66±1.58) points, which were significantly lower than (22.57±4.02) points, (19.46±2.87) points, (17.39±2.13) points,and (15.39±2.21) points in the control group (P<0.05). The PSQI scores of the observation group after 1 week, 2 weeks,4 weeks and 8 weeks of treatment were (12.21±1.79) points, (9.77±1.35) points, (6.79±1.12) points, and (5.08±1.19) points, which were significantly lower than (14.79±1.83) points, (12.70±1.69) points, (10.79±1.32) points, and(9.49±1.74) points of the control group (P<0.05). After treatment, the total effective rate of the observation group was86.67%, which was significantly higher than 60.00% of the control group (P<0.05). There was no significant differencein the incidence of adverse reactions between the two groups. Conclusion Oral administration of Wuling capsule com-bined with stellate ganglion block in the treatment of anxiety insomnia can significantly relieve the symptoms such asanxiety and insomnia of patients, and had no obvious side effect in the treatment process, which can be promoted and ap-plied in clinical practice.
      【Key words】 Anxiety insomnia; Wuling capsules; Ultrasound; Stellate ganglion block; Efficacy