标题：维持性血液透析与腹膜透析患者中血清碱性磷酸酶、超敏肌钙蛋白 I的表达水平及对心脏结构的影响

      作者：李富强 1，吕晶 2，熊礼娟 1    1.安康市中医医院肾病科，陕西 安康 725000；2.西安交通大学第一附属医院肾病科，陕西 西安 710000

      卷次： 2022年33卷6期

      【摘要】 目的 研究维持性血液透析与腹膜透析患者中血清碱性磷酸酶(ALP)、超敏肌钙蛋白 I (hs-cTnI)的表达水平及对心脏结构的影响。方法 回顾性分析2018年1月至2020年5月安康市中医医院肾病科收治的86例行透析治疗患者的临床资料，根据透析方式不同分为维持性血液透析组(n=42)和腹膜透析组(n=44)。比较两组患者治疗前后的血清ALP、hs-cTnI水平和治疗前后的心脏结构变化。结果 两组患者治疗后的血清hs-cTnI和ALP水平均明显低于治疗前，且腹膜透析组患者治疗后的血清 hs-cTnI和ALP水平分别为(70.44±5.89) ng/mol和(50.14±5.44) U/L，明显低于维持性血液透析组的(90.54±5.44) ng/mol和(70.93±5.56) U/L，差异均具有统计学意义(P<0.05)；两组患者治疗后的 LVEDD、LAD、LVPWDT均明显高于治疗前，且腹膜透析组患者治疗后的 LVEDD、LAD和LVPWDT分别为(46.89±1.89) mm、(42.55±5.08) mm和(15.55±1.23) mm，明显高于维持性血液透析组的(43.54±1.44) mm、(37.21±5.19) mm和(12.54±1.35) mm，差异均具有统计学意义(P<0.05)。结论 维持性血液透析和腹膜透析对患者的血清ALP、hs-cTnI水平及心脏结构均存在一定的影响，但腹膜透析治疗对患者改善程度更大。
      【关键词】 血清碱性磷酸酶；超敏肌钙蛋白 I；维持性透析；腹膜透析；心脏结构
      【中图分类号】 R459.5 【文献标识码】 A 【文章编号】 1003—6350（2022）06—0711—03

Expression of serum alkaline phosphatase and high-sensitivity cardiac Troponin I in patients on maintenancehemodialysis and peritoneal dialysis and its influence on cardiac structure.
LI Fu-qiang 1, LV Jing 2, XIONG Li-juan 1.1. Department of Nephrology, Ankang Hospital of Traditional Chinese Medicine, Ankang 725000, Shaanxi, CHINA; 2.Department of Nephrology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi, CHINA
【Abstract】 Objective To study the expression of serum alkaline phosphatase (ALP) and high-sensitivity cardi-ac troponin I (hs-cTnI) levels in patients on maintenance hemodialysis and peritoneal dialysis and their effects on cardiacstructure. Methods The clinical data of eighty-six patients undergoing dialysis in Department of Nephrology, AnkangHospital of Traditional Chinese Medicine from January 2018 to May 2020 were retrospectively analyzed, and patientswere classified into maintenance hemodialysis group (n=42) and peritoneal dialysis group (n=44) according to the dialy-sis methods. Serum levels of ALP and hs-cTnI, and the cardiac structure were compared between the two groups at thebaseline and after treatment. Results After treatment, serum levels of ALP and hs-cTnI were decreased in bothgroups, and the levels of two indicators were (70.44±5.89) ng/mol and (50.14±5.44) U/L in peritoneal dialysis group,which were significantly lower than (90.54±5.44) ng/mol and (70.93±5.56) U/L in maintenance hemodialysis group(P<0.05). After treatment, the left ventricular end-diastolic dimension (LVEDD), left atrial diameter (LAD), and leftventricular posterior wall end-diastolic thickness (LVPWDT) were increased in both groups, and the values of three pa-rameters were (46.89±1.89) mm, (42.55±5.08) mm, and (15.55±1.23) mm in peritoneal dialysis group, which were sig-nificantly higher than (43.54±1.44) mm, (37.21±5.19) mm, and (12.54±1.35) mm in maintenance hemodialysis group(P<0.05). Conclusion Both peritoneal dialysis and maintenance dialysis have impact on serum ALP and hs-cTnI levelsand cardiac function of patients, while peritoneal dialysis results in greater clinical improvement than maintenance dialysis.
      【Key words】 Alkaline phosphatase; High-sensitivity cardiac troponin I; Maintenance hemodialysis; Peritoneal di-alysis; Cardiac structure