标题：子痫前期患者血清 sFlt-1、activin A水平与氧化应激和新生儿结局的相关性

      作者：王瑞 1，乔媛 2，刘娟弟 3    西北妇女儿童医院产科 1、高危产科 2、妇科 3，陕西 西安 710061

      卷次： 2022年33卷5期

      【摘要】 目的 探讨子痫前期(PE)患者血清可溶性血管内皮生长因子受体-1 (sFlt-1)、激活素A (activin A)水平与氧化应激、新生儿结局的相关性。方法 选取 2017年 1月至 2020年 10月西北妇女儿童医院收治的 180例PE患者为PE组，另选取同期来本院住院分娩的健康产妇 50例作为对照组。检测并比较两组产妇的血清 sFlt-1、activin A、超氧化物歧化酶(SOD)、丙二醛(MDA)及总抗氧化能力(T-AOC)水平，随访新生儿结局。采用相关性分析方法(Pearson、Spearman)分析 PE组患者血清 sFlt-1、activin A水平与氧化应激、新生儿结局之间的相关性。结果 PE组患者的血清 sFlt-1、activin A水平分别为(216.97±47.36) pg/mL、(5.75±1.51) ng/mL，明显高于对照组的(29.73±5.74) pg/mL、(2.44±0.70) ng/mL，差异均有统计学意义(P<0.05)；PE组患者的血清MDA、SOD、T-AOC水平分别为(4.70±1.60) μmol/L、(81.50±19.21) U/mL、(10.23±2.13) U/mL，对照组分别为(3.15±0.87) μmol/L、(103.29±24.77) U/mL、(13.63±2.41) U/mL，PE组患者的血清MDA明显高于对照组，但SOD、T-AOC水平明显低于对照组，差异均有统计学意义(P<0.05)；PE组患者的不良新生儿结局总发生率为17.78%，明显高于对照组的6.00%，差异有统计学意义(P<0.05)；经 Pearson和 Spearman相关性分析结果显示，PE组患者 sFlt-1、activin A水平均与MDA水平(r=0.729 9、0.771 8，P<0.01)和新生儿结局 (r=0.573 0、0.632 9，P<0.001)呈正相关，与 SOD (r=-0.723 2、-0.734 6，P<0.001)、T-AOC水平(r=-0.707 5、-0.758 1，P<0.001)呈负相关。结论 PE患者血清 sFlt-1、activin A水平异常升高，且与氧化应激、新生儿结局关系密切。
      【关键词】 子痫前期；可溶性血管内皮生长因子受体-1；激活素A；氧化应激；新生儿结局；相关性
      【中图分类号】 R714.24+5 【文献标识码】 A 【文章编号】 1003—6350（2022）05—0567—03

Correlation between serum sFlt-1, activin A levels and oxidative stress, neonatal outcomes in pre-eclampsiapatients.
WANG Rui 1, QIAO Yuan 2, LIU Juan-di 3. Department of Obstetrics 1, Department of High-risk Obstetrics 2,Department of Gynaecology 3, Northwest Women's and Children's Hospital, Xi'an 710061, Shaanxi, CHINA
【Abstract】 Objective To explore the correlation between serum soluble vascular endothelial cell growth fac-tor receptor-1 (sFlt-1), activin A levels and oxidative stress, neonatal outcomes in patients with pre-eclampsia (PE).Methods A total of 180 patients with PE admitted to Northwest Women's and Children's Hospital were enrolled asPE group between January 2017 and October 2020, and other 50 healthy puerperae undergoing delivery during thesame period were enrolled as control group. The levels of serum sFlt-1, activin A, superoxide dismutase (SOD), malo-ndialdehyde (MDA) and total antioxidant capacity (T-AOC) in the two groups were detected and compared. Neonataloutcomes were followed up. The correlation between serum sFlt-1, activin A levels and oxidative stress, neonatal out-comes in PE group was analyzed by Pearson and Spearman analysis. Results The levels of serum sFlt-1 and activin Ain PE group were (216.97±47.36) pg/mL and (5.75±1.51) ng/mL, significantly higher than (29.73±5.74) pg/mL and(2.44±0.70) ng/mL in the control group (P<0.05). The levels of serum MDA, SOD and T-AOC in PE group were (4.70±1.60) μmol/L, (81.50±19.21) U/mL, and (10.23±2.13) U/mL, versus (3.15±0.87) μmol/L, (103.29±24.77) U/mL, and(13.63±2.41) U/mL in the control group, respectively. The level of serum MDA in PE group was significantly higherthan that in control group (P<0.05), while SOD and T-AOC were significantly lower than those in the control group (P<0.05). The total incidence of adverse neonatal outcomes in PE group was significantly higher than that in control group(17.78% vs 6.00%, P<0.05). The results of Pearson and Spearman correlation analysis showed that sFlt-1 and activin Alevels were positively correlated with MDA level (r=0.729 9, 0.771 8, P<0.001) and neonatal outcomes (r=0.573 0,0.632 9, P<0.001), while negatively correlated with SOD (r=-0.723 2, -0.734 6, P<0.001) and T-AOC (r=-0.707 5, -0.758 1, P<0.001) levels. Conclusion The levels of serum sFlt-1 and activin A are abnormally increased in PE patients, which areclosely related to oxidative stress and neonatal outcomes.
      【Key words】 Pre-eclampsia; Soluble vascular endothelial growth factor receptor-1; Activin A; Oxidative stress;Neonatal outcome; Correlation