标题：维生素D辅助治疗对感染性腹泻患儿血清25(OH)D3与血清因子的影响

      作者：胡玉玲 1，高永伟 2，王栋梅 3，马文玲 4    1.延安市中医医院儿科，陕西 延安 716000；2.延安大学附属医院儿科，陕西 延安 716000；3.延安市人民医院儿科，陕西 延安 716000；4.延安市志丹县人民医院儿科，陕西 延安 717500

      卷次： 2022年33卷4期

      【摘要】 目的 观察维生素D辅助治疗感染性腹泻对患儿血清中25(OH)D3及血清因子的影响。方法 选取2018年6月至2020年6月于延安市中医医院儿科就诊的感染性腹泻患儿120例，按照随机数表法分为对照组和观察组，每组60例。对照组患儿给予常规治疗,观察组患儿在对照组治疗的基础上给予维生素D滴剂，两组患者均治疗72 h。比较两组患儿的临床疗效及不良反应，以及治疗前及治疗72 h后的白介素-6 (IL-6)、白介素-7 (IL-7)、白介素-23 (IL-23)及肿瘤坏死因子-α (TNF-α)和25(OH)D3水平。结果 治疗后，观察组患儿的的临床总有效率为98.33%，明显高于对照组的 78.33%，差异有统计学意义(P<0.05)；观察组患儿治疗过程中的总不良反应发生率为6.67%，略低于对照组的 11.67%，但差异无统计学意义(P>0.05)；治疗前，两组患者的血清 25(OH)D3、IL-6、IL-7、IL-23及 TNF-α水平比较差异均无统计学意义(P>0.05)；治疗 72 h后，两组患儿的血清 25(OH)D3水平明显升高，IL-6、IL-7、IL-23及TNF-α水平明显下降，且观察组患儿的血清 25(OH)D3明显高于对照组，IL-6、IL-7、IL-23及TNF-α水平明显低于对照组，差异均有统计学意义(P<0.05)。结论 维生素D用于感染性腹泻的治疗具有良好的临床疗效，且可提高患儿血清中维生素D含量，减轻炎症反应，安全性高。
      【关键词】 感染性腹泻；维生素D；血清25-羟维生素D3；血清因子；疗效
      【中图分类号】 R725.7 【文献标识码】 A 【文章编号】 1003—6350（2022）04—0479—04

Effect of Vitamin D adjuvant therapy on serum 25(OH)D3 and serum factors in children with infectious diarrhea.HU Yu-ling 1, GAO Yong-wei 2, WANG Dong-mei 3, MA Wen-ling 4.
1. Department of Pediatrics, Yan'an TraditionalChinese Medicine Hospital, Yan'an 716000, Shaanxi, CHINA; 2. Department of Pediatrics, Yan'an University AffiliatedHospital, Yan'an 716000, Shaanxi, CHINA; 3. Department of Pediatrics, Yan'an People's Hospital, Yan'an 716000,Shaanxi, CHINA; 4. Department of Pediatrics, Zhidan County People's Hospital, Yan'an 717500, Shaanxi, CHINA
【Abstract】 Objective To observe the effects of vitamin D adjuvant treatment of infectious diarrhea on serum25(OH)D3 and serum factors in children.Methods A total of 120 children with infectious diarrhea treated in the Depart-ment of Pediatrics at Yan'an Traditional Chinese Medicine Hospital from June 2018 to June 2020 were selected and divid-ed into a control group and an observation group according to the random number table method, with 60 cases in eachgroup. Children in the control group were given routine treatment, and children in the observation group received vita-min D drops on the basis of treatment in the control group. Both groups were treated for 72 hours. The clinical efficacyand adverse effects were compared between the two groups, as well as the levels of interleukin-6 (IL-6), interleukin-7(IL-7), interleukin-23 (IL-23), tumor necrosis factor-α (TNF-α), and 25(OH)D3 before treatment and 72 hours aftertreatment. Results After treatment, the total clinical efficiency of children in the observation group was 98.33%, whichwas significantly higher than 78.33% in the control group, and the difference was statistically significant (P<0.05). Thetotal incidence of adverse reactions during the treatment in the observation group was 6.67%, slightly lower than 11.67%in the control group (P>0.05). Before treatment, there was no significant difference in the levels of serum 25(OH)D3,IL-6, IL-7, IL-23, and TNF-α (P>0.05). After 72 hours of treatment, the serum 25(OH)D3 levels of the two groups in-creased significantly, the levels of IL-6, IL-7, IL-23, and TNF-α decreased significantly; and the serum 25(OH)D3 wassignificantly higher in the observation group than in the control group, and the levels of IL-6, IL-7, IL-23, and TNF-αwere significantly lower than those of the control group (P<0.05). Conclusion Vitamin D has a good clinical effect inthe treatment of infectious diarrhea. It can increase the content of vitamin D in the serum of children, reduce inflammato-ry response, and have high safety.
      【Key words】 Infectious diarrhea; Vitamin D; 25(OH)D3; Serum factor; Curative effect