标题：男性生殖器硬化性苔藓样变发病机制与治疗的最新进展

      作者：杨健 1，谢文贤 2，曾柯 1    1.自贡市第一人民医院泌尿外科，四川 自贡 643000；2.四川省卫生康复职业学院基础教研室，四川 自贡 643000

      卷次： 2022年33卷1期

      【摘要】 男性生殖器硬化性苔藓样变(MGLSc)是一种慢性炎症性皮肤病，常引起男性性交困难和前尿道狭窄，甚至可演变成阴茎鳞状细胞癌(PSCC)。虽然发病原因众多，但是长期的尿液浸蚀而引起包皮、龟头慢性炎症是最核心的病理机制。对于早期MGLSc的治疗方法是局部使用皮质类固醇激素；对于药物治疗无效、尿道狭窄、鳞状细胞癌的患者应进行手术治疗。光动力治疗具有微创、无毒、安全便捷等优点，对于早期的MGLSc患者可能是一种理想的治疗方式。
      【关键词】 男性生殖器硬化性苔藓样变；感染；阴茎鳞状细胞癌；微尿失禁；光动力治疗
      【中图分类号】 R699 【文献标识码】 A 【文章编号】 1003—6350（2022）01—0108—05

Recent advances in the pathogenesis and treatment of male genital lichen sclerosus.
YANG Jian 1, XIE Wen-xian 2,ZENG Ke 1. 1. Department of Urology, Zigong First People's Hospital, Zigong 643000, Sichuan, CHINA; 2. Department ofBasic Medicine, Sichuan Vocational College of Health And Rehabilitation, Zigong 643000, Sichuan, CHINA【Abstract】 Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease, which often causesmale sexual difficulties and anterior urethral stricture, and even develops into penile squamous cell carcinoma (PSCC).Although there are many causes, chronic inflammation of prepuce and glans caused by long-term urine erosion is thecore pathological mechanism. The treatment of early MGLSc is local corticosteroid. Surgical treatment should be per-formed in patients with drug failure, urethral stricture and squamous cell carcinoma. Photodynamic therapy is minimallyinvasive, non-toxic, safe and convenient, which may be an ideal treatment for early MGLSc patients.
      【Key words】 Male genital lichen sclerosus (MGLSc); Infection; Penile squamous cell carcinoma (PSCC); Mi-cro-incontinence; Photodynamic therapy·综述·doi:10.3969/j.issn.1003-6350.2022.01.030基金项目：四川省自贡市卫生健康委员会科研课题(编号：20zd004)