标题：α7-烟碱型乙酰胆碱受体与动脉粥样硬化斑块稳定性的研究进展

      作者：李宇鸿 1 综述 何前松 2 审校    1.贵州中医药大学研究生院，贵州 贵阳 550002；2.贵州中医药大学第二临床医学院，贵州 贵阳 550003

      卷次： 2022年33卷1期

      【摘要】 近年研究发现，α7亚型乙酰胆碱受体(α7nAChR)在许多病理生理学过程中起关键作用，其病理生理学过程涉及炎症调控、血管重塑等多个方面。然而，α7nAChR的异常调节与动脉粥样硬化形成密切相关。实际上，α7nAChR在抗炎和血管新生作用中就像一把双刃剑。文章综述了α7nAChR在动脉粥样硬化炎症反应、斑块内新生血管中的作用及对动脉粥样硬化斑块稳定性的影响，为动脉粥样硬化的治疗提供新的思考。
      【关键词】 α7-烟碱型乙酰胆碱受体；抗炎通路；动脉粥样硬化；血管新生；斑块稳定性
      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350（2022）01—0103—05

Research progress of α7-nicotinic acetylcholine receptor and the stability of atherosclerotic plaques.
LI Yu-hong 1,HE Qian-song 2. 1. Graduate School 1, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, Guizhou, CHINA;2. The Second Clinical Medical College 2, Guizhou University of Traditional Chinese Medicine, Guiyang 550003, Guizhou,CHINA【Abstract】 In recent years, it has been found that a7 nicotinic acetylcholine receptor (a7nAChR) plays a key rolein many pathophysiological processes and its pathophysiological process involves inflammatory regulation, vascular re-modeling and other aspects. However, the abnormal regulation of a7nAChR is closely related to the formation of athero-sclerosis. In fact, a7nAChR is like a double-edged sword in anti-inflammatory and angiogenesis. This paper reviews therole of a7nAChR in the inflammatory response, neovascularization, and stability of atherosclerotic plaque, in order toprovide new ideas and theories for the treatment of atherosclerosis.
      【Key words】 α7-nicotinic acetylcholine receptor; Anti-inflammatory pathway; Atherosclerosis; Neovasculariza-tion; Plaque stability·综述·doi:10.3969/j.issn.1003-6350.2022.01.029