标题：白细胞介素-1β、白细胞介素-6与肿瘤坏死因子-α在非酒精性脂肪性肝病发展过程中的作用

      作者：赵鹏，金海，朱加兴 综述 庹必光 审校    遵义医科大学附属医院消化内科，贵州 遵义 563003

      卷次： 2022年33卷1期

      【摘要】 非酒精性脂肪性肝病(NAFLD)是最常见的肝病，其发生与肥胖关系密切，但其发病机制目前尚未完全明确，越来越多的证据表明，除了代谢异常外，肥胖引起的全身慢性非特异性炎症也在NAFLD的发生发展中发挥重要作用。本文总结了白细胞介素-1β，白细胞介素-6、肿瘤坏死因子-α等3种肥胖时体内升高的炎性细胞因子在NAFLD的各阶段，包括非酒精性脂肪肝、非酒精性脂肪肝炎、肝纤维化、肝硬化和肝细胞癌等阶段所发挥的作用，以期为寻找NAFLD预防及治疗的新方法提供相关参考。
      【关键词】 非酒精性脂肪肝；炎症；肝硬化；细胞因子；白细胞介素
      【中图分类号】 R575.5 【文献标识码】 A 【文章编号】 1003—6350（2022）01—0096—04

Role of interleukin-1β, interleukin-6 and tumor necrosis factor-α in the development of nonalcoholic fatty liverdisease.
ZHAO Peng, JIN Hai, ZHU Jia-xing, TUO Bi-guang. 1. Department of Gastroenterology, Affiliated Hospital ofZunyi Medical University, Zunyi 563003, Guizhou, CHINA【Abstract】 Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and its occurrence isclosely related to obesity. But its pathogenesis is not yet fully understood. More and more evidences show that, in addi-tion to metabolic abnormalities, systemic chronic nonspecific inflammation caused by obesity also plays an importantrole in the occurrence and development of NAFLD. In this study, we reviewed the role of inflammatory cytokines in-creased in obesity, including interleukin-1β, interleukin-6, and tumor necrosis factor-α, in various stages of NAFLD, in-cluding nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatic fibrosis, cirrhosis, and hepatocellular carci-noma, in order to provide relevant reference for finding new methods of the prevention and treatment of NAFLD.
      【Key words】 Nonalcoholic fatty liver disease (NAFLD); Inflammation; Cirrhosis of the liver; Cytokines; Inter-leukin·综述·doi:10.3969/j.issn.1003-6350.2022.01.027基金项目：国家自然科学基金(编号：81960507)