标题：弥凝联合托特罗定治疗儿童原发性夜遗尿临床观察

      作者：郭银霞，肖小兵，邓建荣，胡瑛，高盈竹，钟美香    粤北人民医院儿科，广东 韶关 512025

      卷次： 2022年33卷1期

      【摘要】 目的 观察弥凝联合托特罗定治疗儿童原发性夜遗尿的临床疗效及安全性。方法 选择2018年1月至2020年8月粤北人民医院儿科门诊收治的60例原发性夜遗尿患儿作为研究对象，按照随机数表法分为观察组和对照组各30例。对照组患儿在常规措施基础上采用弥凝治疗，观察组在对照组治疗的基础上联合托特罗定治疗，均持续治疗 3个月。比较两组患儿治疗 3个月后的临床疗效，治疗前、治疗 3个月后的夜间遗尿次数、夜间遗尿尿量的变化，以及停药后 1个月、3个月的复发率和治疗期间不良反应发生情况。结果 治疗后，观察组患儿的临床治疗总有效率为 93.33%，明显高于对照组的 73.33%，差异有统计学意义(P<0.05)；治疗后，观察组患儿的夜间遗尿次数、夜间遗尿尿量分别为(1.17±0.20)周、(101.45±12.02) mL，明显少于对照组的(1.45±0.23)周、(111.43±10.87) mL，差异均有统计学意义(P<0.05)；观察组患儿停药后 1个月、3个月的复发率分别为3.33%和6.67%，明显低于对照组的20.00%和26.67%，差异均有统计学意义(P<0.05)；观察组和对照组患儿不良反应总发生率分别为13.33%和10.00%，差异无统计学意义(P>0.05)。结论 弥凝联合托特罗定治疗儿童原发性夜遗尿的临床疗效明显，值得临床推广。
      【关键词】 原发性夜遗尿；儿童；弥凝；托特罗定；疗效；不良反应
      【中图分类号】 R726.9 【文献标识码】 A 【文章编号】 1003—6350（2022）01—0065—03

Clinical observation of desmopressin combined with tolterodine in the treatment of primary nocturnal enuresis inchildren.
GUO Yin-xia, XIAO Xiao-bing, DENG Jian-rong, HU Ying, GAO Ying-zhu, ZHONG Mei-xiang. Department ofPediatrics, North Guangdong People's Hospital, Shaoguan 512025, Guangdong, CHINA
【Abstract】 Objective To study the curative efficacy of desmopressin combined with tolterodine in the treat-ment of primary nocturnal enuresis in children. Methods A total of 60 patients of primary nocturnal enuresis, who ad-mitted to the Outpatient Department of pediatrics, North Guangdong People's Hospital from January 2018 to August2020, were selected and divided into the observation group and control group according to random number table method,with 30 patients in each group. The control group was treated with desmopressin on the basis of conventional measures,while the observation group was combined with tolterodine on the basis of the control group. The treatment lasted 3months. The clinical effects at 3 months after treatment, the nocturnal enuresis frequency and nocturnal enuresis urinevolume before and at 3 months after treatment, and the recurrence rate at 1 month and 3 months after drug withdrawaland the incidence of adverse reactions during treatment of two groups children were compared. Results After treat-ment, the total effective rate in the observation group was 93.33%, which was significantly higher than 73.33% of thecontrol group (P<0.05); after treatment, the nocturnal enuresis frequency and nocturnal enuresis urine volume in theobservation group were (1.17±0.20) weeks and (101.45±12.02) mL, which were significantly less than corresponding(1.45±0.23) weeks and (111.43±10.87) mL of the control group (P<0.05); after 1 month and 3 months drug withdrawal,the recurrence rates in the observation group were 3.33% and 6.67%, which were significantly lower than corresponding20.00% and 26.67% of the control group (P<0.05); the total incidence of adverse reactions in the observation group was13.33% versus 10.00% in the control group (P>0.05). Conclusion Desmopressin combined with tolterodine in thetreatment of children with primary nocturnal enuresis has obvious clinical effect and is worthy of clinical promotion.
      【Key words】 Primary nocturnal enuresis; Children; Desmopressin; Tolterodine; Efficacy; Adverse reactions