标题：乳腺浸润性导管癌BI-RADS分级与雌激素受体、孕激素受体及人表皮生长因子受体表达的关系

      作者：冯建丽，马蓉，杨洋，吴红梅    宝鸡市人民医院病理科，陕西 宝鸡 721000

      卷次： 2021年32卷24期

      【摘要】 目的 探讨乳腺浸润性导管癌乳腺影像报告和数据系统(BI-RADS)分级与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体(HER-2)表达的关系。方法 回顾性分析宝鸡市人民医院 2018—2020年收治的100例乳腺浸润性导管癌患者的临床资料，记录所有患者的超声征象、BI-RADS分级和ER、PR、HER-2阳性率，并比较乳腺浸润性导管癌ER、PR、HER-2阳性、阴性患者的BI-RADS分级情况。结果 100例患者的ER、PR、HER-2阳性率分别为63.00%、57.00%、46.00%；有毛刺征患者ER、PR阳性率分别为78.79%、78.79%，明显高于无毛刺征患者的55.22%、46.27%，有微钙化患者的HER-2阳性率为54.55%，明显高于无微钙化患者的29.41%，差异均有统计学意义(P<0.05)；血流分级Ⅱ~Ⅲ级患者的ER、PR、HER-2阳性率分别为69.05%、61.90%、51.19%，明显高于血流分级0~Ⅰ级患者的31.25%、31.25%、18.75%，差异均有统计学意义(P<0.05)；ER、PR、HER-2阳性患者乳腺浸润性导管癌BI-RADS分级明显高于阴性患者，差异均有统计学意义(P<0.05)。结论 乳腺浸润性导管癌ER、PR、HER-2阳性表达患者BI-RADS分级明显更高，临床实践中可以将其联合应用，更有助于鉴别患者疾病情况。
      【关键词】 乳腺浸润性导管癌；乳腺影像报告和数据系统分级；雌激素受体；激素受体；人表皮生长因子受体
      【中图分类号】 R737.9 【文献标识码】 A 【文章编号】 1003—6350（2021）24—3134—04

Relationship between breast imaging reporting and data system grading and expression of estrogen receptor,progesterone receptor, and human epidermal growth factor receptor 2 in breast infiltrating ductal carcinoma.FENG Jian-li, MA Rong, YANG Yang, WU Hong-mei.
Department of Pathology, Baoji People's Hospital, Baoji 721000,Shaanxi, CHINA
【Abstract】 Objective To investigate the relationship between breast imaging reporting and data system(BI-RADS) grading and the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermalgrowth factor receptor 2 (HER-2) in breast infiltrating ductal carcinoma. Methods The clinical data of 100 patientswith breast infiltrating ductal carcinoma in Baoji People's Hospital from 2018 to 2020 were retrospectively analyzed.The ultrasonic signs, BI-RADS grading and the positive rates of ER, PR, and HER-2 were recorded. The BI-RADSgrades of ER, PR and HER-2 positive and negative patients with breast infiltrating ductal carcinoma were compared.Results The positive rates of ER, PR, and HER-2 in 100 patients were 63.00%, 57.00%, and 46.00%, respectively.The positive rates of ER and PR in patients with spicule sign were 78.79% and 78.79%, which were significantly higherthan 55.22% and 46.27% in patients without spicule sign; the positive rate of HER-2 in patients with microcalcificationwas 54.55%, which was significantly higher than 29.41% in patients without microcalcification (P<0.05). The positiverates of ER, PR, and HER-2 in patients with blood flow grade Ⅱ~Ⅲ were 69.05%, 61.90%, and 51.19%, which weresignificantly higher than 31.25%, 31.25%, 18.75% in patients without spicule sign of blood flow grade 0-Ⅰ (P<0.05).The BI-RADS grade of breast invasive ductal carcinoma in ER, PR and HER-2 positive patients were significantly high-er than that in negative patients, with statistically significant differences (P<0.05). Conclusion The BI-RADS grade issignificantly higher in patients ER, PR and HER-2 positive expression in breast invasive ductal carcinoma. It can beused in combination in clinical practice, which is more helpful to identify the disease situation of patients.
      【Key words】 Breast infiltrating ductal carcinoma; Breast imaging reporting and data system grading; Estrogen re-ceptor; Hormone receptor; Human epidermal growth factor receptor