标题：ADMA在短暂性脑缺血发作发病机制中的研究进展

      作者：张国芳 综述 刘安祥，张骏 审校    遵义医科大学附属医院神经内科，贵州 遵义 563000

      卷次： 2021年32卷23期

      【摘要】 短暂性脑缺血发作(TIA)是一种常见于卒中高危患者的脑血管疾病。TIA是脑组织血液供应一过性中断的一类疾病，循环中多种因子与其相关脑血管功能紊乱、结构障碍存在较强相关性。目前，TIA的发病机制仍不清楚，近来有研究发现血清非对称性二甲基精氨酸(ADMA)可能参与了TIA的病理过程，并逐渐在TIA的发生发展中扮演着重要的作用。本文拟对ADMA与TIA发病相关的研究进展做一综述。
      【关键词】 非对称性二甲基精氨酸；脑卒中；短暂性脑缺血发作；脑缺血；一过性缺血
      【中图分类号】 R743.31 【文献标识码】 A 【文章编号】 1003—6350（2021）23—3111—04

Mechanism of asymmetric dimethylarginine in the pathogenesis of transient ischemic attack.
ZHANG Guo-fang,LIU An-xiang, ZHANG Jun. Department of Neurology, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000,Guizhou, CHINA【Abstract】 Transient ischemic attack (TIA) is a common cerebrovascular disease with transient interruption ofblood supply in brain, which exists in patients with high risk factors of stroke. Various risk factors in circulation havebeen shown strong correlation with the function and structural disorder of TIA. At present, the pathogenesis of TIA isstill unclear. Recently, it has been found that asymmetric dimethylarginine (ADMA) may be involved in the pathologicalprocess of TIA and may even play an increasingly essential role in the development of TIA. Therefore, this article sum-marizes the research situation and prospect of ADMA and TIA.
      【Key words】 Asymmetric dimethylarginine (ADMA); Stroke; Transient ischemic attack (TIA); Brain ischemia;Transient ischemic·综述·doi:10.3969/j.issn.1003-6350.2021.23.033基金项目：国家自然科学基金(编号：81760225)