标题：Fibro Touch参数与慢性乙型病毒性肝炎患者血糖及胰岛素水平的相关性

      作者：林淑珍，张晓静，张志安，刘志华，齐青松    东莞市厚街医院感染科，广东 东莞 523945

      卷次： 2021年32卷23期

      【摘要】 目的 探究 Fibro Touch参数与慢性乙型病毒性肝炎(CHB)患者血糖及胰岛素水平的相关性。方法 选取 2019年 4月至 2020年 10月期间东莞市厚街医院收治的 168例CHB患者作为研究对象，按照肝纤维化程度分为 F0期 19例，F1期 29例，F2期 40例，F3期 51例，F4期 29例。采用 Fibro Touch检查测定其肝硬度测定值(LSM)，比较不同肝纤维化分期 CHB患者的谷丙转氨酶(ALT)、总胆红素(TBIL)、LSM、糖化血红蛋白(HbAlc)和胰岛素水平，采用Spearman相关性分析LSM、HbAlc和胰岛素之间的相关性。结果 随着肝纤维分期的不断增加，ALT、TBIL、LSM、HbA1c水平呈现逐渐上升的趋势，胰岛素水平呈现逐渐下降的趋势，差异均有统计学意义(P<0.05)；CHB患者的LSM水平与HbA1c水平呈正相关(r=0.382，P<0.01)，LSM水平与胰岛素水平、HbAlc水平与胰岛素水平均呈负相关(r=-0.412、-0.336，P<0.01)。结论 Fibro Touch检查测定CHB患者的LSM水平与其血糖和胰岛素水平具有相关性。Fibro Touch检查与血糖、胰岛素水平在评估CHB患者肝纤维化程度上具有一定的临床应用价值。
      【关键词】 Fibro Touch参数；肝硬度测定值；慢性乙型病毒性肝炎；瞬时弹性成像技术；糖化血红蛋白；胰岛素
      【中图分类号】 R512.6+2 【文献标识码】 A 【文章编号】 1003—6350（2021）23—3103—03

Correlation analysis of Fibro Touch parameters with blood glucose and insulin levels in patients with chronichepatitis B.
LIN Shu-zhen, ZHANG Xiao-jing, ZHANG Zhi-an, LIU Zhi-hua, QI Qing-song. Department of InfectiousDisease, Dongguan Houjie Hospital, Dongguan 523945, Guangdong, CHINA
【Abstract】 Objective To explore the correlation between Fibro Touch parameters and the levels of blood glu-cose and insulin in patients with chronic hepatitis B (CHB). Methods The 168 CHB patients admitted to DongguanHoujie Hospital from April 2019 to October 2020 were selected as the research objects. According to the degree of liverfibrosis, there were 19 cases in F0 stage, 29 cases in F1 stage, 40 cases in F2 stage, 51 cases in F3 stage, and 29 cases inF4 stage. Fibro Touch test was used to measure the liver stiffness measure (LSM) values. The levels of alanine amino-transferase (ALT), total bilirubin (TBIL), LSM, glycosylated hemoglobin (HbAlc) and insulin were compared in CHBpatients with different stages of liver fibrosis. Spearman correlation was used to analyze the correlation between LSM,HbAlc and insulin. Results With the continuous increase of hepatic fiber staging, the levels of ALT, TBIL, LSM andHbA1c increased gradually, and the level of insulin decreased gradually (P<0.05). The LSM level was positively correlat-ed with HbA1c level in CHB patients (r=0.382, P<0.01), LSM level was negatively correlated with insulin level, andHbAlc level was negatively correlated with insulin level (r=-0.412, -0.336, P<0.01). Conclusion The Fibro Touch de-termines that the LSM level of CHB patients is correlated with their blood glucose and insulin levels. Fibro Touch exami-nation and blood glucose and insulin levels have certain clinical application value in evaluating the degree of liver fibro-sis in patients with CHB.
      【Key words】 Fibre Touch parameters; Liver stiffness measure values; Chronic hepatitis B; Transient elastogra-phy; Glycosylated hemoglobin; Insulin·短篇论著·doi:10.3969/j.issn.1003-6350.2021.23.030基金项目：广东省东莞市社会科技发展一般项目(编号：201950715023449)