标题：PET/CT显像对宫颈癌局部复发诊断价值的Meta分析

      作者：王彤，孙洪赞，张军    中国医科大学附属盛京医院放射科，辽宁 沈阳 110004

      卷次： 2021年32卷21期

      【摘要】 目的 系统评价正电子发射/计算机断层扫描 (PET/CT)对复发性宫颈癌诊断的临床应用价值。方法 通过检索中国知网、维普、万方、中国生物医学文献数据库和 PubMed、EMBASE、Cochrane图书馆等数据库，收集PET/CT诊断复发性宫颈癌的相关文献。检索日期为从建库开始至 2020年 7月。严格按照纳入及排除标准筛选文献、提取数据，质量评价使用QUADAS-2工具独立进行，再采用Meta-Disc1.4和 Stata 15.0软件评价文献异质性，计算合并特异性(SPE)、敏感度(SEN)、阳性似然比(+LR)、阴性似然比(-LR)、诊断比值比(DOR)和绘制汇总受试者工作特征曲线(SROC)，计算曲线下面积(AUROC)。结果 最终纳入符合标准的文献20篇，共有 1 047例患者。Meta分析合并总体效应量分别为：SEN合并0.97 (95%CI：0.95~0.98)、SPE合并0.85 (95%CI：0.79~0.89)、+LR合并6.4 (95%CI：4.7~8.7)、-LR合并0.03 (95%CI：0.02~0.05)、DOR 200 (95%CI：111~359)、SROC曲线下面积AUC 0.97 (95%CI：0.95~0.98)，验前和验后概率(+LR，-LR)为20%和62%、1%。结论 PET/CT在宫颈癌局部复发诊断中具有较高的敏感性和诊断准确率，能显示良好的解剖定位和功能代谢信息，也为临床治疗方式的选择提供了有价值的参考依据。
      【关键词】 正电子发射/计算机断层扫描；宫颈癌；复发；临床诊断；Meta分析
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2021）21—2819—06

Value of PET/CT imaging in the diagnosis of local recurrence of cervical cancer: a meta-analysis.
WANG Tong,SUN Hong-zan, ZHANG Jun. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004,Liaoning, CHINA
【Abstract】 Objective The clinical value of PET/CT in the diagnosis of recurrent cervical cancer. Methods Therelevant literatures on PET/CT diagnosis of recurrent cervical cancer were collected by searching the databases of CNKI,Wanfang, VIP, China Biomedical Literature Database and PubMed, EMBASE, Cochrane Library. The retrieval date wasfrom inception to July 2020. Literature selection and data extraction were conducted in strict accordance with the crite-ria. Quality evaluation was conducted independently according to the QUADAS-2 tools. Heterogeneity was evaluatedby Meta-disc1.4 and Stata 15.0 software. The combined sensitivity (SEN), specificity (SPE), positive likelihood ratio(+LR), negative likelihood ratio (-LR), diagnostic ratio (DOR), working characteristic curve (SROC), and area under thecurve (AUROC) were calculated. Results In the end, 20 literatures meeting the criteria were included, with a total of1 047 patients. Meta-analysis showed that the combined total effect of sensitivity was 0.97 (95%CI: 0.95-0.98), specifici-ty was 0.85 (95%CI: 0.79-0.89), positive likelihood ratio was 6.4 (95%CI: 4.7-8.7), negative likelihood ratio was 0.03(95%CI: 0.02-0.05), diagnostic ratio was 200 (95%CI: 111-359), the area under the SROC curve was 0.97 (95% CI:0.95-0.98), and the pre- and post-test probability (+LR, -LR) were 20% and 62%, 1%. Conclusion PET/CT has highsensitivity and diagnostic accuracy in the diagnosis of local recurrence of cervical cancer, and can display good anatomi-cal location and functional metabolic information, which also provides valuable reference for the selection of clinicaltreatment.
      【Key words】 Positron emission tomography computed tomography; Cervical cancer; Recurrent; Clinical diagno-sis; Meta-analysis·荟萃分析·doi:10.3969/j.issn.1003-6350.2021.21.027基金项目：辽宁省重点研发计划指导项目(编号：2017225012)