标题：miRNA-144在食管癌中的研究进展桃卓嫣综述 吴伟东，古佳升审校

      作者：暨南大学附属广州红十字会医院心胸外科，广东 广州 510220    

      卷次： 2021年32卷21期

      【摘要】 microRNA (miRNA)是一类非编码RNA。近年来，科学家们发现miRNA能在人体内不同类型的恶性肿瘤中表达，并对细胞增殖、凋亡，以及肿瘤细胞的侵袭、迁移等有一定影响。我国是食管癌的高发国家之一，由于该疾病存在早期难以发现，中晚期治疗困难，预后较差的情况，目前在临床上拥有一定的治疗难度，对广大人民的健康存在较大威胁。有研究表明，miRNA-144的表达与食管癌存在着密切联系，本文就miRNA-144在食管癌中的最新研究作一综述。
      【关键词】 miRNA；miRNA-144；食管癌；恶性肿瘤；临床治疗；研究进展
      【中图分类号】 R735.1 【文献标识码】 A 【文章编号】 1003—6350（2021）21—2800—04

Research progress of miRNA-144 in esophageal cancer.
TAO Zhuo-yan, WU Wei-dong, GU Jia-sheng. Department ofCardiothoracic Surgery Guangzhou Red Cross Hospital Affiliated to Jinan University, Guangzhou 510220, Guangdong, CHINA【Abstract】 MicroRNA (miRNA) is a type of non-coding RNAs. In recent years, scientists have discovered thatmiRNAs can be expressed in different types of malignant tumors in the human body, and have certain effects on cell pro-liferation, apoptosis, tumor cell invasion and migration. China is one of countries with high incidence of esophageal can-cer. Since the disease is difficult to detect in the early stage, difficult to treat in the middle and late stages, and has a poorprognosis, it is clinically difficult to treat and poses a greater threat to the health of the general public. It has been shownthat the expression of miRNA-144 is closely related to esophageal cancer. This article reviews the latest research onmiRNA-144 in esophageal cancer.
      【Key words】 miRNA; miRNA-144; Esophageal cancer; Tumor; Clinical treatment; Research progress·综述·doi:10.3969/j.issn.1003-6350.2021.21.022基金项目：广东省广州市科技创新发展专项资金项目(编号：201902010003)