标题：氯吡格雷抵抗基因多态性与短暂性脑缺血发作的相关性研究进展

      作者：李娟 1 综述 喻明 1，2 审校    1.遵义医科大学附属医院神经内科，贵州 遵义 563000；2.遂宁市中心医院神经内科，四川 遂宁 629000

      卷次： 2021年32卷20期

      【摘要】 短暂性脑缺血发作(TIA)也被称为卒中先兆，是缺血性脑卒中发生的重要危险因素。因此，对TIA患者早期的诊断及有效的治疗对于预防TIA进展为缺血性脑卒中具有极其重要的临床意义。而氯吡格雷作为TIA治疗的一线用药，其在TIA患者个体间代谢的差异性将影响TIA患者抗血小板治疗的疗效及预后。研究表明，氯吡格雷代谢相关基因的多态性引起个体对氯吡格雷吸收、代谢的差异，可导致不同TIA患者对氯吡格雷抗血小板治疗的临床疗效不同。本文通过对氯吡格雷抵抗相关基因多态性与TIA相关性的研究进行概述，以期为TIA的基因检测提供文献依据，指导TIA患者临床抗血小板用药的选择，为TIA患者提供精准医疗模式。
      【关键词】 短暂性脑缺血发作；氯吡格雷抵抗；基因多态性；CYP2C19基因；ABCB1基因
      【中图分类号】 R743.31 【文献标识码】 A 【文章编号】 1003—6350（2021）20—2681—04

Research progress on the correlation between clopidogrel resistance-related gene polymorphisms and transientischemic attack.
LI Juan 1, YU Ming 1,2. 1. Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi563000, Guizhou, CHINA; 2. Department of Neurology, Suining Central Hospital, Suining 629000, Sichuan, CHINA【Abstract】 Transient ischemic attack (TIA), also known as stroke aura, is a major risk factor for ischemic stroke.Therefore, the early diagnosis and effective treatment of TIA patients have extremely important clinical significance forpreventing TIA from progressing to ischemic stroke. Clopidogrel is the first-line medication for TIA, and its metabolicdifferences among TIA patients will affect the efficacy and prognosis of antiplatelet therapy in TIA patients. Studies haveshown that the polymorphism of clopidogrel metabolism-related genes cause individual differences in the absorption andmetabolism of clopidogrel, which may lead to different clinical efficacy of clopidogrel antiplatelet therapy in differentTIA patients. This paper summarizes the studies on the correlation between clopidogrel resistance-related gene polymor-phisms and TIA, in order to provide literature basis for the genetic testing of TIA, guide the clinical selection of antiplate-let medication for TIA patients, and provide precision medicine model for TIA patients.
      【Key words】 Transient ischemic attack; Clopidogrel resistance; Gene polymorphism; CYP2C19 gene; ABCB1gene·综述·doi:10.3969/j.issn.1003-6350.2021.20.026