标题：BMP9与非酒精性脂肪性肝病关系的研究进展

      作者：牛梦璠，刘睿宸 综述 李丽 审校    哈尔滨体育学院，黑龙江 哈尔滨 150008

      卷次： 2021年32卷20期

      【摘要】 骨形态发生蛋白 9 (BMP9)是参与调控软骨形成、血管生成、神经元分化等复杂信号通路的关键分子，非酒精性脂肪性肝病(NAFLD)特点在于肝内甘油三酯的堆积及肝脏病变的持续进展。近年来研究发现BMP9与NAFLD之间有一定相关性。本文主要就BMP9通过促进褐色脂肪细胞生成、增加胰岛素敏感性，调控脂质代谢相关蛋白及肝纤维化方面对NAFLD的影响及两者相互关系进行综述。
      【关键词】 骨形态发生蛋白9；非酒精性脂肪性肝病；脂质代谢；肝纤维化
      【中图分类号】 R575 【文献标识码】 A 【文章编号】 1003—6350（2021）20—2677—04

Research progress on the relationship between BMP9 and nonalcoholic fatty liver disease.
NIU Meng-fan, LIURui-chen, LI Li. Harbin Institute of Physical Education, Harbin 150008, Heilongjiang, CHINA【Abstract】 Bone morphogenetic protein 9 (BMP9) is a key molecule involved in the regulation of cartilage for-mation, angiogenesis, neuron differentiation and other complex signaling pathways. Nonalcoholic fatty liver disease(NAFLD) is characterized by the accumulation of triglycerides in the liver and the continuous progress of liver disease.In recent years, studies have found that there is a certain correlation between BMP9 and NAFLD. This article mainly re-views the effects of BMP9 on NAFLD by promoting the formation of brown adipocytes, increasing insulin sensitivity,regulating lipid metabolism related proteins and liver fibrosis, and the relationship between them.
      【Key words】 Bone morphogenetic protein 9 (BMP9); Nonalcoholic fatty liver disease (NAFLD); Lipid metabo-lism; Liver fibrosis·综述·doi:10.3969/j.issn.1003-6350.2021.20.025基金项目：黑龙江省自然科学基金(编号：LH2020H011)