标题：内服替硝唑外用荆芥水煎液治疗阴道滴虫病的疗效及其对患者血清白介素-2、白介素-4和白介素-10的影响

      作者：师亚娥 1，白桂芹 2，张美荣 1，姜海燕 1
    (1.铜川市人民医院南院妇产科，陕西 铜川 727100；
2.西安交通大学第一附属医院妇产科，陕西 西安 710061)

      卷次： 2016年27卷18期

      【摘要】 目的 观察替硝唑口服联合荆芥水煎液外用治疗阴道滴虫病的疗效，并探讨其对患者血清白介素
(IL)-2、IL-4和 IL-10水平的影响。方法 平行设计选取2013年1月至2016年1月铜川市人民医院南院和西安交
通大学第一附属医院妇产科符合阴道滴虫病的患者随机分为对照组和观察组，每组60例。对照组予替硝唑口服治
疗，观察组在对照组治疗的基础上予荆芥水煎液阴道外用，治疗14 d。观察两组患者临床症状和体征改善的所需
时间；显微镜检查阴道分泌物悬液；酶联免疫法检测患者治疗前后的血清 IL-2、IL-4和 IL-10水平；随访3个月以观
察复发情况。结果 观察组患者的总有效率为90.0% (55/60)，明显高于对照组的73.3% (44/60)，差异有统计学意义(P<
0.05)；两组患者治疗前后血清 IL-2、IL-4和 IL-10浓度水平比较，差异均有统计学意义(P<0.05)；观察组治疗前后血清
IL-2、IL-10浓度差值明显多于对照组[(6.5±2.7) pg/mL vs (3.6±1.7) pg/mL，(6.8±2.6) pg/mL vs (2.6±0.9) pg/mL]，差异均
有统计学意义(P<0.05)，而观察组治疗前后血清 IL-4浓度差值稍多于对照组，但差异无统计学意义(P>0.05)；随访3
个月，对照组复发率为 18.3% (4/60)，明显高于观察组的 6.7% (11/60)，差异有显著统计学意义(P<0.01)。结论 替
硝唑口服联合荆芥水煎液外用能够治疗阴道滴虫病，症状改善与复发率方面明显优于单一使用抗滴虫药物，其可
能通过抗滴虫治疗与局部调节炎症反应从而提高疗效。

      【关键词】 阴道滴虫病；替硝唑；荆芥；白细胞介素；疗效

      【中图分类号】 R711.73 【文献标识码】 A 【文章编号】 1003—6350（2016）18—3003—03


Clinical observation of tinidazole combined with schizonepeta in the treatment of Trichomoniasis vaginalis and
effects on the serum concentrations of IL-2, IL-4 and IL-10.
Shi Ya-er 1, Bai Gui-qin 2, Zhang Mei-rong 1, Jiang
Hai-yan 1. 1. Department of Obstetrics and Gynaecology, Southern Branch of Tongchuan People's Hospital, Tongchuan
727100, Shaanxi, CHINA; 2. Department of Obstetrics and Gynaecology, the First Hospital Affiliated to Xi'an Jiaotong
University, Xi'an 710061, Shaanxi, CHINA

【Abstract】 Objective To investigate the clinical effect of tinidazole combined with schizonepeta in the treat-
ment of Trichomoniasis vaginalis (TV), and to study the effects on the serum concentrations of IL-2, IL-4 and IL-10.
Methods A total of 120 cases of patients with TV, who admitted to Tongchuan People’s hospital and the First Hospital
Affiliated to Xi'an Jiaotong University during January 2013 to January 2016, were randomly divided into control and
treatment group with a parallel-group design, with 60 patients in each group. Patients in control group were routinely
treated with tinidazole for 14 days, while those in the treatment group were additionally treated with schizonepeta for ex-
ternal use based on the control group. The required time for alleviating the signs and symptoms were observed, and vagi-
nal secretions were collected to be tested by the microscope. The serum concentrations of IL-2, IL-4 and IL-10 before
and after treatment were tested by enzyme-linked immunosorbent assay (ELISA), and all the patients were followed up
in 3 months to investigate the recurrence rate. Results The total effective rate of treatment group was 90.00% (55/60),
which was significantly higher than 73.33%(44/60) in the control group (P<0.05). The serum concentrations of IL-2,
IL-4 and IL-10 before and after the treatment had statistically significant difference in each group (P<0.05). Moreover,
the difference of the IL-2 and IL-10 before and after the treatment in the treatment group were significantly more than
the control group ((6.5±2.7) pg/mL vs (3.6±1.7) pg/mL, (6.8±2.6) pg/mL vs (2.6±0.9) pg/mL), P<0.05. The difference of
IL-4 in the treatment group before and after treatment was a little more than the control group, but there was no statisti-
cal significance (P>0.05). In addition, the recurrence rate of control group 18.3% (4/60) was significantly higher than
that of the treatment group 6.7% (11/60) in the follow up of 3 months, P<0.01. Conclusion It was of great effective-
ness to use tinidazole combined with schizonepeta in treatment of TV, which was much better than simply using the antit-
richomonal agents on the improvement of symptoms and the recurrence. Furthermore, it may be related to the regulation
the local inflammation as well as and the antitrichomonal effect, which could be the major mechanism to improve the cu-
rative effect.
[Key words] Trichomoniasis vaginalis; Tinidazole; Schizonepeta; Interleukin; Efficacy
·论 著·
6350.2016.18.027