标题：2013-2015年海口地区妇女高危型HPV感染状况

      作者：李红，林香桃
    (中南大学湘雅医学院附属海口医院病理科，海南 海口 570208)

      卷次： 2016年27卷18期

      【摘要】 目的 调查海口地区妇女高危型人乳头瘤病毒(HPV)感染及分布情况，为今后宫颈癌及癌前病变筛
查及防治提供依据。方法 收集 2013年 1月至 2015年 9月在我院就诊的 10 840例妇女的宫颈脱落细胞，运用
Cervista酶切信号放大检测实验行高危型HPV检测及分型组(依据病毒DNA序列相近性分为A5/A6、A7、A9组)。
依据年龄分为青年组(20~29岁)，中青年组(30~39岁)，中年组(40~49岁)，中老年组(50~59岁)和老年组(≥60岁)。统
计分析高危型HPV感染与各年龄的关系及各型组分布情况。结果 10 840例标本中共检出高危型HPV阳性者
2 010例，感染总阳性率为18.54%，以老年组患者感染率最高(27.61%)，其次为中老年组(22.00%)，以中青年组感染
率最低(16.87%)，差异有显著统计学意义(P<0.01)。A9组(包括单重及双重)感染率最高(9.65%)，A7组(包括单重及
双重)感染率最低(4.65%)，差异有显著统计学意义(P<0.01)。结论 海口地区妇女高危型HPV感染率具有随年龄
增加而增加的趋势，以A9组感染率最高，对今后HPV疫苗研究及早期筛查治疗提供依据。

      【关键词】 海口地区；高危型人乳头瘤病毒；感染

      【中图分类号】 R730.261 【文献标识码】 A 【文章编号】 1003—6350（2016）18—2998—03


Investigation on the infection status of high-risk HPV in women in Haikou from 2013-2015.
LI Hong, LIN
Xiang-tao. Department of Pathology, Haikou Municipal Hospital Affiliated to Xiangya School of Medicine, Central South
University, Haikou 570208, Hainan, CHINA

【Abstract】 Objective To investigate the infection status and distribution situation of high-risk (HR) humanpap-
illoma vires (HPV) in women in Haikou to provide evidence for screening and prevention of cervical cancer and precan-
cerous lesions in the future. Methods A total of 10 840 women of cervical exfoliated cells from January 2013 to Sep-
tember 2015 in our hospital were collected. Cervista HPV HR test was used to detect high-risk HPV and typing (classi-
fied into A5/A6, A7 and A9 group based on similarity of the virus DNA sequence). The patients were divided into
young group (20 to 29 years old), middle-young-aged group (30 to 39 years old), middle-aged group (40 to 49 years
old), middle-elderly-aged group (50 to 59 years old) and elderly group (60 years old or older) on the basis of age. The
relationship between high-risk HPV infection and age, and the distribution of each group were statistically analyzed.
Results A total of 2 010 positive cases of high-risk HPV were detected in 10 840 cases, and the total positive rate was
18.54%. The infection rate of elderly group was the highest (27.61%), followed by middle-elderly-aged group (22.00%),
and the infection rate of middle-young-aged group was the lowest (16.87%), with statistically significant differences (P<
0.01). The infection rate of A9 group (both single and dual) was the highest (9.65%), and the infection rate of A7 group
(both single and dual) was the lowest (4.65%), with statistically significant differences (P<0.01). Conclusion The infec-
tion rate of high-risk HPV of women in Haikou area has a increasing trend with age, and the infection rate of A9 group is
the highest, which provides a basis for HPV vaccine research and early screening and treatment of high-risk HPV.

      【Key words】 Haikou; High-risk HPV; Infection
·论 著·
6350.2016.18.025