标题：老年社区获得性细菌性肺炎患者降钙素原的测定及其意义

      作者：王传海，李承红
    (江汉大学附属医院呼吸内科，湖北 武汉 430015)

      卷次： 2016年27卷18期

      【摘要】 目的 探讨老年社区获得性细菌性肺炎患者血清降钙素原(PCT)的变化及其临床意义。方法 选取
2013年6月至2015年6月在我科住院并被确诊为老年社区获得性细菌性肺炎的患者(肺炎组) 80例和同期入院的
老年非肺炎患者(对照组) 80例为研究对象，肺炎组治疗前后及对照组分别测定血清PCT、外周血白细胞(WBC)计
数及红细胞沉降率(ESR)水平，并对检测结果进行比较。结果 肺炎组血清PCT阳性率(80.0%)明显高于外周血
WBC计数(50.0%)、ESR (45.0%)及痰培养(27.5%)，差异均有统计学意义(P<0.01)；治疗前肺炎组和对照组血清PCT
水平分别为(3.12±1.05) ng/mL和(0.45±0.13) ng/mL，两者比较，治疗前肺炎组血清PCT水平显著高于对照组(P<0.01)，
而外周血WBC计数及ESR水平与对照组比较差异无统计学意义(P>0.05)；治疗前、后肺炎组血清PCT水平分别为
(3.12±1.05) ng/mL、(0.48±0.16) ng/mL，两者比较，肺炎组经治疗后血清PCT水平明显降低，与治疗前比较差异有显
著统计学意义(P<0.01)，而外周血WBC计数及ESR水平与治疗前比较差异无统计学意义(P>0.05)。结论 血清PCT
水平较外周血WBC计数、ESR水平更敏感地反映老年社区获得性细菌性肺炎患者炎症变化情况，值得临床重视。

      【关键词】 老年；社区获得性肺炎；细菌性；降钙素原

      【中图分类号】 R563.1 【文献标识码】 A 【文章编号】 1003—6350（2016）18—2969—03


Determination and clinical significance of procalcitonin in elderly patients with community-acquired bacterial
pneumonia.
WANG Chuan-hai, LI Cheng-hong. Department of Respiratory Medicine, Affiliated Hospital of Jianghan
University, Wuhan 430015, Hubei, CHINA

【Abstract】 Objective To investigate the changes and clinical significance of serum procalcitonin (PCT) in el-
derly patients with community-acquired bacterial pneumonia. Methods Eighty elderly patients diagnosed as communi-
ty-acquired bacterial pneumonia treated in our hospital from June, 2013 to June, 2015 were selected as the pneumonia
group, and 80 elderly patients without pneumonia were selected as the control group. Serum PCT, peripheral white blood
cell (WBC), erythrocyte sedimentation rate (ESR) were measured and compared between the two groups. Results The
positive rate of serum PCT in pneumonia group was 80.0%, which was significantly higher than that of WBC (50.0%), ESR
(45.0%) and sputum culture (27.5%), P<0.01. Before treatment, the serum PCT level of pneumonia group was significant-
ly higher than that in control group ((3.12±1.05) ng/mL vs (0.45±0.13) ng/mL, P<0.01), but there was no significant differ-
ence in WBC, ESR between the two groups (P>0.05). Compared with before treatment, the serum PCT level of pneumonia
group after treatment were significantly decreased ((0.48±0.16) ng/mL vs (3.12±1.05) ng/mL, P<0.01), but there was no sig-
nificant difference in WBC, ESR in pneumonia group after treatment (P>0.05). Conclusion Serum PCT level is more
sensitive than WBC and ESR for inflammation change in elderly patients with community-acquired bacterial pneumonia.

      【Key words】 Elderly; Community-acquired pneumonia; Bacterial; Procalcitonin (PCT)
·论 著·
6350.2016.18.015